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PPP spring > Sex Hormones > Flashcards

Sex Hormones Flashcards

1
Q

Estradiol

Estrogen

A

Moa: E binds to R and goes to gene transcription to produce the protein

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2
Q

Ethinyl estradiol

15-20x more potent

A
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3
Q

Slow estrogen MOA

A

E binds to R and goes to gene transcription to produce the protein

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4
Q

Rapid Estrogen MOA

A

E binds to R and activates a kinase to send signals

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5
Q

Subtypes MOA

A

Alpha and Beta and CF can varries the level and type of estrogen

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6
Q

Estrogen effects

development, nervous, cardio, meta, hepatic

A

Dev: too much = risk of breat cancer
Ner: menopause and hot flashes
cardio: increase clotting factors and stroke, meno:dyslipidemia, Paradoxial HTN, edema and bloating
Meta and hep: TGC, gallstone, ORAL - toxic and lees bio
Repo: meno: abnormal bleeding, Imbalance endometrosis or edno cancer
Skelet: meno: osteoprosis

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7
Q

HRT CI

A

Breast cancer, liver disease, stroke, DVT, CVD,

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8
Q

Estrogen to right patient ( uterus intact, uterus absent, Moderate CVD)

A
  1. intact - estro and proge
  2. absent - estrogen
  3. mod CVD - no oral
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9
Q

Progestins

A

ner: drowsy, body temp increase, weight gain
repo: decreas sperm motility, supporess ovulation (decrease GnRH enchacned with estrogen), matures lining

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10
Q

Estrogen and progestin levels: high and low

A

estrogen - low= Early cycle breakthrough, hypomenorrhea or amenorrhea
excess = clotting, cancer parodoxial HTN

Progestin - Low = late cycle breakthrough, HYPERmenorrhea
excess = hypomenorrhea or amenorrhea

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11
Q

When to not give E and P

A

CVD, DVT/PE, Afib, Stroke, Smoker >35

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12
Q

When to not give P

A

8 hr HL, need perfect adherance, same time each day

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13
Q

E+P dosage forms

A
  1. monophasic
  2. multiphasic increase and decreasing does
  3. extended interval dont want periods: improve endometriosis PMDD
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14
Q

Medroxyprogesterone

A

potent and longer HF

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15
Q

norethindrone

A

1st gen testoterone
OCP = pogesterone only
moderate androgen

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16
Q

norgestrel

A

2nd gen
mostly androgenic and so less Estrogen side effects more like ance and hair growth

17
Q

norgestimate

A

3rd gen and less androgenic

18
Q

dospirenone

A

spironolactone derivative

19
Q

Testosterone concerns

A

all preg catagory X

20
Q

Testosterone concern

A

all preg catagory X

21
Q

Testosterone Effects

A

Ner: excess agression def depression
card: stroke, DVt, heart attack, dyslipidemia, Edema HTN DEF: anemia
meta and hepatic: insulin resitance, imbalance dyslipidemia
Repo: BPH growth, cancer, decrease libido
Muscle: defficent: weakness and osteoprosis
nero: baldness, acne, hirsutism

22
Q

Testosterone formulation

A

never oral all parental routes

23
Q

Oxandrolone

A

oral modified androgen

24
Q

Degarelix

A

MOA: GnRH antagonist
Use: Hormone dependent cancers

25
Q

Goserelin

A

MOA: GnRH agonist (increased GnRH has inhibitory effects)
Use: Cancers but not common bc agonist you get Hormone flare
Note: if useing for cancer need to co administer with GnRH antagonsit

26
Q

Anastrozle

A

MOA: Aromatase inhibitior blocks Testosterone to Estradiol
Use: breast cancer

27
Q

Finasteride, Dutasteride

A

MOA: (5-alpha-reductase) testosterone to Dihydrotestosterone
Use: BPH or baldness

28
Q

Abiraterone

A

MOA: 17-hydroxylase inhibitor (blocks progesterone to testosterone)
Use: Prostate Cancer
Notes: need to be admin with steriod bc you block coritcoid

29
Q

Tamoxifen

A

MOA:SERM
Agonist: Bone, cholesterol, Uterus
Antagonist: Breast
Use: Breast Cancer

30
Q

Raloxifene

A

MOA: SERM
Agonist: Bone, Cholesterol
Antagonist: Breast, Uterus
Use: Breast cancer, osteoporosis

31
Q

Ulipristal

A

MOA: SPRM
Use: emergecy contraception

32
Q

Fulvestrant

A

MOA: Estrogen receptor blocker
Use: Breast Cancer

33
Q

Mifeprostone

A

MOA: Progestin Receptor Blocker
Use: Medical abortion (W/ misoprostol)

34
Q

Bicalutamide

A

MOA: Strong Androgen receptor blocker
Use: Prostate cancer

35
Q

Spironolactone

A

MOA: Weak Androgen receptor blocker
use: Hirsutism, primary hyperaldosteronism, hypokalemia, HF
AD:Hyperkalemia, hyponatremia, Gynecomastia

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