Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PPP spring > AntiPlatelet > Flashcards

AntiPlatelet Flashcards

1
Q

Platelet degranulation release what

A

ADP, 5HT, and more

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Platelet secretion releases what?

A

TXA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

which step if blocked stops coagulation

A

4th crosslinking

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

PAR-1 and TP Pathway

A

q -> PLC -> DAG + IP3, DAG to PKC, IP3 to CA | CA to [PLA2] to make AA from phospholipids, [COX1] take AA to make TXA to trigger TP ( makes q to make PLC) | betagamma from PAR-1 and TP make GP-2b/3a activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

P2y-12 pathway

A

ADP -> i inhbits adenylyl cyclase -> cAMP inhibits 1-4 | PDE inhibts cAMP [want cAMP]

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

COX -1 COX-2

A

1 stomach and TXA 2 PGI and blood vessels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Asprin

A

irreve and non select but more on cox-1, longest effect bc life of platelet and usually taken at breakfast to avoid DDI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

NSAID

A

non select reversible, due to this no thera platelet blocking

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Celecoxib

A

selective 2 but increased clotting risk, used to avoid Cox-1 stomach stuff

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Clopidogrel

A

Thienopyridines (P2y12) - 2 step (CYP 2C19)
2hr onset
DDI WITH OMEP
Irreversible
Q24H

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Prasugrel

A

Thienopyridines (P2y12) 1 step by (3A4, 2B6)
30 MIN ONSET
Irreversible
Q24H

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Ticagrelor

A

reversible P2y12 inhibitor
BID
8hr HL
30 min onset

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Cangrelor

A

reversible P2y12 inhibitor
IV
5min HL
2 min onset

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Dipyridamole, Cilostazol

A

PDE inhibit
Cil - for claudiaction
Dip - for 2nd stroke

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Vorapaxar

A

PAR-1 inhibitor Reversible
3-4 day HL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

SSRI

A

block 5HT
INCREASE GI BLEEDS
not used for therapy but more for side effect warning

17
Q

Abciximab

A

Blocks Gp-2a/3b (IRREVERSIBLE LIKE)
antibody fragment
30 HL and 7day effect
PROTEOLYTIC

18
Q

Eptifibatide

A

Blocks GP-2a/3b - reversible
cyclic 7 blocker
2.5 hr HL
effect 4-8hrs
RENAL ELIMINATION 50%

19
Q

Tirofiban

A

GP3
reversible nonpeptide
renal eliminated 65%
4-8hr effect

PPP spring (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions