Immuno drugs Flashcards
Cyclosporine and Tacrolimus
Blocks T cell sig 1 ( inhibits calcineurin)
Used: Organ transplant and RA
AE: infections and malignancies (all immuno drugs), Nephro and HT
Belatacept
MOA: CTLA-4 bindings to B7
used: acute kidney, Epstein Barr virus
AE: infection and malignancies (PTLD)
Natalizumab
MOA: inhibit T cell Extravasation (X VTLA-4 into INFLAMED TISSUE)
Used: MS
AE: infections and malignancies, PML
Rituximab
MOA: CD20 in B cells to cause death by NK (ADCC or Complement)
Used: RA, SLE, MS, non-hodge lymphoma
AE: hep b reaction and PML
Prednisone
MOA: bind to GCR
Used: organ, chronic inflam, RA, MS
AE: Cushing disease (weight gain, weak skin, moonface, weak bone, fluid retention
Infliximab
MOA: mAb prevents TNF from activating receptors
Used: Organ trans, Chronic inflam, Autoimmune disease
AE:Infections and malignancies RISK OF TUBERCULOSIS
Anakinra
MOA: Prevents IL-R activation
Indication: hereditary Fever
AE: Infections and Malignancies
Tocilizumab
MOA: Binds to IL-6 and reduces inflame effects
Indication: RA
AE: infections and malignancies
Cetuximab
MOA: mAb blocks EGF signaling pathway (growth) and activates kill pathway
Indication: EGFR expressing tumors
AE: rash Diarrhea
Trastuzumab
MOA: mAb to HER-2 to block and on cells to kill
Indication: HER-2 expressing tumors
Anti-CTLA-4 mAb
MOA: blocks the block on T cells activation
Indication: Melanoma
AE: excessive T cell inflammation
Anti PDL,PD-L1 mAb
MOA: inhibits PDL so T cells can kill cancer cells (PDL expressed and inhibitory factor on cancer cells)
Indication: solid and blood cancers
AE: excessive T cell inflammation
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Omalizumab
MOA: stop IgE to load onto mast cell
Hepolizumab
MOA: lessen recruitment of eosinophils
