Dyslipidemia

Question 1

Statin

Answer 1

MOA: x HMG coa to lower inner cholesterol
Use: Fisrt line therapy
1. 30-63 LDL
2. 35-45 TG
3. 5-15 HDL increase
AD: hepatic toxic, skel(myoloid, myopathy,mysostis) renal
Notes: Factors - higher statins, DD interaction, Low thyroid, low Vit D X pregnacy
Test: LFT and Creatine

Question 2

Ezitimibe

Answer 2

MOA: x inner NPC1L1 (lower chole and increase uptake LDL-R)
Use: 18-22 LDL

Question 3

Chole/cole

BA

Answer 3

MOA: binds BA in instestine to release and lower inner cholesterol to trigger LDL-R
Use:
1. 15-25 LDL
2. 3-10 TG raise
AD: GI bloating, reduce fatty vit and GI drug absorption

Question 4

Alirocumab, Evolocumab

Answer 4

MOA: x PCSK-9 to recycle more LDL-R
Use: Best LDL lower 70%
AD: injection rxn and allergic rxn

Question 5

Niacin

Answer 5

MOA: Gi on fatty cells decrease LDL-C, Also blocks liver TG synthesis
Use:
1. 20-30 LDL
2. 35-40 TG
3. Best HDL raiser 30-40%
AD: flushing itch, Hepa, hyperglycemic, hyperuricemia
DDI: SKM w/ statins

Question 6

Fenofibrozil, Gemfibrozil

Answer 6

MOA: Activates PPAR⍺ to clear more TG and lower VLDL
Use:
1. Best TG lower 50%
2. 15 HDL
AD: GI, gallstones, SKM w/ statins gemfib