Sex Development Flashcards
The presence of the ___ gene leads to testes development at week 9
SRY
Which hormone leads to regression of female structures?
Anti-Mullerian hormone
What does the Mullerian duct develop into?
Fallopian tubes, uterus and upper third of vagina
What does the Wolffian duct develop into?
epididymis, vas deferens, seminal vesicles and ejaculatory duct
Sertoli cells secrete ___ which leads to regression of the Mullerian system
AMH
Which cells make testosterone in the testis?
Leydig cells
Testosterone is under the control of ___ early on in male development, and __ later in development.
hCG (human-chorionic gonadotrophin)
LH
What is the top layer of the adrenal gland called?
Zona glomerulosa
What is the middle layer of the adrenal gland called?
Zona fasciculata
What is the innermost layer of the adrenal gland?
Zona reticularis
Absence of SRY gene on Y chromosome leads to ovaries being present by weeks __-__
11-12
Testosterone is converted to ___ by 5 alpha-reductase enzyme
DHT
DHT leads to formation of what structures?
Penis, scrotum and prostate
Before testis or ovary develop, it is a b__________ gonad
bipotential
Patients with DSD (differences in sex development) are at risk of _______ failure
adrenal
Which cells in the testis produce AMH?
Sertoli cells
Which cell in the testis produce testosterone which converts into DHT?
Leydig cells
What happens as a result of AMH?
Mullerian duct regression (no fallopian tube, ovary and vaginal development)
What receptor is needed for DHT to cause development of male external genitalia and for testosterone for internal genitalia development?
Adrenal receptors
In girls, testosterone is converted to 17 beta-o________ by aromatase
oestradiol
The precursor to testosterone, andro-stenedione also can convert into _______ by aromatase
Oestrone
(get s converted to 17 B-oestradiol)
What do ER bind with?
17B-oestradiol
