Sex Development

Question 1

The presence of the ___ gene leads to testes development at week 9

Answer 1

SRY

Question 2

Which hormone leads to regression of female structures?

Answer 2

Anti-Mullerian hormone

Question 3

What does the Mullerian duct develop into?

Answer 3

Fallopian tubes, uterus and upper third of vagina

Question 4

What does the Wolffian duct develop into?

Answer 4

epididymis, vas deferens, seminal vesicles and ejaculatory duct

Question 5

Sertoli cells secrete ___ which leads to regression of the Mullerian system

Answer 5

AMH

Question 6

Which cells make testosterone in the testis?

Answer 6

Leydig cells

Question 7

Testosterone is under the control of ___ early on in male development, and __ later in development.

Answer 7

hCG (human-chorionic gonadotrophin)
LH

Question 8

What is the top layer of the adrenal gland called?

Answer 8

Zona glomerulosa

Question 9

What is the middle layer of the adrenal gland called?

Answer 9

Zona fasciculata

Question 10

What is the innermost layer of the adrenal gland?

Answer 10

Zona reticularis

Question 11

Absence of SRY gene on Y chromosome leads to ovaries being present by weeks __-__

Answer 11

11-12

Question 12

Testosterone is converted to ___ by 5 alpha-reductase enzyme

Answer 12

DHT

Question 13

DHT leads to formation of what structures?

Answer 13

Penis, scrotum and prostate

Question 14

Before testis or ovary develop, it is a b__________ gonad

Answer 14

bipotential

Question 15

Patients with DSD (differences in sex development) are at risk of _______ failure

Answer 15

adrenal

Question 16

Which cells in the testis produce AMH?

Answer 16

Sertoli cells

Question 17

Which cell in the testis produce testosterone which converts into DHT?

Answer 17

Leydig cells

Question 18

What happens as a result of AMH?

Answer 18

Mullerian duct regression (no fallopian tube, ovary and vaginal development)

Question 19

What receptor is needed for DHT to cause development of male external genitalia and for testosterone for internal genitalia development?

Answer 19

Adrenal receptors

Question 20

In girls, testosterone is converted to 17 beta-o________ by aromatase

Answer 20

oestradiol

Question 21

The precursor to testosterone, andro-stenedione also can convert into _______ by aromatase

Answer 21

Oestrone
(get s converted to 17 B-oestradiol)

Question 22

What do ER bind with?

Answer 22

17B-oestradiol