Sevoflurane

Question 1

Sevoflurane boiling point

Answer 1

58.5 C

Question 2

Sevoflurane saturated vapor pressure

Answer 2

157 mmHg

Question 3

Sevoflurane MAC

Answer 3

2.0 vol%

Question 4

Sevoflurane blood/gas coefficient

Answer 4

0.69

Question 5

Sevoflurane brain/blood coefficient

Answer 5

1.7

Question 6

Sevoflurane muscle/blood coefficient

Answer 6

3.1

Question 7

Sevoflurane fat/blood coefficient

Answer 7

48

Question 8

Sevoflurane pulmonary effects

Answer 8

Medium amount (more than N2O) of decreased tidal volume- decreases minute ventilation and increase in end tidal CO2 (same as halothane). Respiratory depressant with very slight tachypnea. Least airway irritation- great for inhalation induction

Question 9

Sevo CV Effects

Answer 9

Dose dependent decrease in myocardial contractility (similar to iso), CO (more than Iso), arterial vasodilation (less than iso) & SVR (less than iso).
Decrease in myocardial contractility causes decrease MVO2 & decrease coronary vascular resistance
No sympathetic nervous system activity
No coronary steal
No incidence of ventricular arrhythmias

Question 10

Sevo renal effects

Answer 10

Oxidatively metabolized to hexafluoroisopropanol formaldehyde, inorganic fluoride & CO2 – can cause renal failure though none have been reported. Belief is that free fluoride may cause inhibition of renal tubular function including chloride transport in ascending limb of the loop of Henle which leads to concentrating effect - just avoid those with renal disease/damage.

Question 11

Sevo liver:blood coefficient

Answer 11

1.8

Question 12

Sevo kidney:blood coefficient

Answer 12

1.2