Desflurane

Question 1

Desflurane boiling point

Answer 1

23.5 C

Question 2

Desflurane saturated vapor pressure

Answer 2

669.2 mmHg

Question 3

Desflurane MAC

Answer 3

6.0 vol%

Question 4

Desflurane blood/gas coefficient

Answer 4

0.42

Question 5

Desflurane brain/blood coefficient

Answer 5

1.3

Question 6

Desflurane fat/blood coefficient

Answer 6

27

Question 7

Desflurane muscle/blood coefficient

Answer 7

2.0

Question 8

Des Pulmonary effects

Answer 8

Most decrease in tidal volume and increase in end tidal CO2 (equal to iso). Extremely noxious pulmonary irritant, not good choice for inhalation induction and best to avoid patients with reactive airway disease. Respiratory depressant, causes slight tachypnea

Question 9

Des CV effects

Answer 9

If autonomic responses are removed- provides myocardial depression & arterial vasodilation similar to iso.. if not blunted will cause less but with more tachycardia. Autonomic Tone important for Des
Abrupt increases in Des leads to increased BP (30 mmHg) & increased HR (30 BPM)- doubling sympathetic nervous system activity and plasma epi concentrations.
Does not cause coronary steal

Question 10

Des liver:blood coefficient

Answer 10

1.4

Question 11

Des kidney:blood coefficient

Answer 11

1