Isoflurane

Question 1

Isoflurane boiling point

Answer 1

48.5 C

Question 2

Isoflurane saturated vapor pressure

Answer 2

239.5

Question 3

Isoflurane MAC

Answer 3

1.15 vol%

Question 4

Isoflurane blood/gas coefficient

Answer 4

1.4

Question 5

Isoflurane brain/blood coefficient

Answer 5

2.6

Question 6

Isoflurane muscle/blood coefficient

Answer 6

4.0

Question 7

Isoflurane fat/blood coefficient

Answer 7

45

Question 8

Iso Pulmonary effects

Answer 8

Most decrease in tidal volume and increase in end tidal CO2 (equal to des). Causes respiratory depression. Less tachypnea than Halothane. MOST depression of ventilatory response to hypoxemia and hypercapnia. Similar hypoxic pulmonary vasoconstrictor response

Question 9

Iso CV effects

Answer 9

Dose dependent decrease in BP from decreased SVR.
Mild myocardial depressant - worse with calcium channel blockers (CO does not increase even though filling pressures raise and SVR drops)..
Mild direct negative chronotropic effect (better than halothane)– will actually result in increased HR from indirect activiation of sympathetic & autonomic nervous system and baroreceptor response to hypotension.
Minimal arrhythmogenicity
Coronary vasodilation & decreased coronary vascular resistance
Does not cause coronary steal

Question 10

Iso burst suppression at what MAC?

Answer 10

1.5, electrical silence at 2 MAC

Question 11

Iso liver:blood coefficient

Answer 11

1.8

Question 12

Iso kidney:blood coefficient

Answer 12

1.2