Session 8 Lecture 2 Flashcards

1
Q

What are the most lethal features of malignant neoplasm?

A

Invasion and metastasis

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2
Q

What increases tumour burden?

A

Ability of malignant cells to invade and spread to distant sites

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3
Q

What will happen if a malignant neoplasm is left untreated?

A

Vast number of parasitic malignancies

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4
Q

What do malignant cells need to do in order to get from a primary site to a secondary site?

A

1) grow and invade at primary site 2) enter a transport system and lodge at secondary site 3) grow at secondary site to form a new tumour

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5
Q

What is colonisation?

A

When malignant cells grow at secondary site to form a new tumour

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6
Q

Is the process of a malignant cell getting from a primary site to a secondary site efficient?

A

No

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7
Q

Why is the process of inefficient?

A
  1. Malignant cells can get damages in the transport system

2. Malignant cell might be unable to grow at secondary site

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8
Q

Invasion into surrounding tissue by carcinoma cells requires…

A

Altered adhesion, strongly proteolysis and motility.

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9
Q

What does EMT stand for?

A

Epithelial to mesenchymal transition

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10
Q

What is EMT?

A

After a carcinoma cell has undergone changes (so it can invade), its phenotype appears more like a mesenchymal cell than a epithelial cell.

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11
Q

What three things lead to EMT?

A

Changes in: adhesion, proteolysis and motility

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12
Q

How is adhesion altered?

A

Changes in integrin expression. Reduction in E-Cadherin expression

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13
Q

How is stromal proteolysis affected?

A

Cell must degrade basement membrane and stoma to invade therefore altered expression of proteases esp MMPs

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14
Q

What does MMP stand for?

A

Matrix metalloproteinases

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15
Q

How is motility altered?

A

Altered motility involves changes in the actin cytoskeleton.

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16
Q

What is a cancer niche?

A

Small environment where cells are binding.

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17
Q

How is a cancer niche formed?

A

Malignant cells take advantage of nearby non-neoplastic cells which together form cancer niche

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18
Q

How are malignant cells transported to distant sites?

A
  • Blood vessels - capillaries and venues
  • lymphatic vessels
  • fluid in body cavities - pleura
19
Q

What is transcoelomic spread?

A

Transmission of malignant tumour through fluid in body cavities - pleura, peritoneal, pericardial and brain ventricles.

20
Q

What is colonisation?

A

The growth of malignant cells at a secondary site

21
Q

What is the greatest barrier to successful formation of metastasis?

A

Failed colonisation

22
Q

Why do you get failed colonisation?

A

Many malignant cells lodge at secondary site but these tiny clusters either die or fail to grow into tumour

23
Q

What are miccometastases?

A

Surviving microscopic deposits of that fail to grow

24
Q

What is tumour dormancy?

A

An apparently disease-free person may harbour many many micrometastases.

25
Q

What determines the site of a secondary tumour?

A
  • Regional drainage of blood, lymph or coelomic fluid.

- The ‘seed and soil’ phenomenon

26
Q

What is the ‘seed and soil’ phenomenon?

A

Embolus of tumour cells will settle down when its finds its niche

27
Q

What does the ‘seed and soil’ phenomenon explain?

A

The seemingly unpredictable distribution of of blood-borne metastasis.

28
Q

How do carcinomas first typically spread?

A

Via lymphatics

29
Q

After spreading through lymphatics, how do carcinomas then spread?

A

Blood

30
Q

What are the common sites of blood borne metastasise?

A

Lung, bone, liver and brain

31
Q

The neoplasms that most frequently spread to bone are…

A

Breast, bronchus, kidney, thyroid and prostrate

32
Q

How do sarcomas tend to spread?

A

Via blood system

33
Q

Give an example of a neoplasm that is more aggressive and metastasise very early

A

Small cell bronchial carcinoma

34
Q

Give an example of a neoplasm that never metastasises

A

Basal cell carcinoma of the skin

35
Q

What is the likelihood of metastasis related to?

A

The size of the primary neoplasm

36
Q

How can we classify the effects neoplasms have on the body?

A

Local and systemic effects

37
Q

What are direct local effects?

A

Due to the primary neoplasm and/or secondary neoplasm

38
Q

What are systemic effect?

A

Indirect. Includes effects of increasing tumour burden, secreted hormones etc

39
Q

What are paraneoplastic syndromes?

A

Clinical syndromes involved in nonmetastatic systemic effects that accompany malignant disease

40
Q

For benign neoplasms, what effects are the most relevant?

A

Local effects form the primary and hormonal effects

41
Q

What are local effects of primary and secondary neoplasms due to?

A

1) direct invasion and destruction of normal tissue 2)ulceration at a surface leading to bleeding 3)compression of adjacent structures 4)blocking tubes and orifices

42
Q

What effects does increasing tumour burden have?

A

Leads to parasitic effects on host. Reduced appetite, weight loss, malaise, immunosuppression and thrombosis

43
Q

What effects doe benign neoplasms of endocrine glands have?

A

The neoplasms are well differentiated so typically produce hormones

44
Q

What miscellaneous systemic effects can neoplasms have?

A

Neuropathic affecting the brain and peripheral nerves, skin problems and abnormal pigmentation.