Session 8 Lecture 2 Flashcards
What are the most lethal features of malignant neoplasm?
Invasion and metastasis
What increases tumour burden?
Ability of malignant cells to invade and spread to distant sites
What will happen if a malignant neoplasm is left untreated?
Vast number of parasitic malignancies
What do malignant cells need to do in order to get from a primary site to a secondary site?
1) grow and invade at primary site 2) enter a transport system and lodge at secondary site 3) grow at secondary site to form a new tumour
What is colonisation?
When malignant cells grow at secondary site to form a new tumour
Is the process of a malignant cell getting from a primary site to a secondary site efficient?
No
Why is the process of inefficient?
- Malignant cells can get damages in the transport system
2. Malignant cell might be unable to grow at secondary site
Invasion into surrounding tissue by carcinoma cells requires…
Altered adhesion, strongly proteolysis and motility.
What does EMT stand for?
Epithelial to mesenchymal transition
What is EMT?
After a carcinoma cell has undergone changes (so it can invade), its phenotype appears more like a mesenchymal cell than a epithelial cell.
What three things lead to EMT?
Changes in: adhesion, proteolysis and motility
How is adhesion altered?
Changes in integrin expression. Reduction in E-Cadherin expression
How is stromal proteolysis affected?
Cell must degrade basement membrane and stoma to invade therefore altered expression of proteases esp MMPs
What does MMP stand for?
Matrix metalloproteinases
How is motility altered?
Altered motility involves changes in the actin cytoskeleton.
What is a cancer niche?
Small environment where cells are binding.
How is a cancer niche formed?
Malignant cells take advantage of nearby non-neoplastic cells which together form cancer niche