session 7 Flashcards
which 4 structures in glomerulus can be damaged
capillary endothelium, glomerular basement membrane, mesangial cells, podocytes
what is diabetic nephopathy
excess glucose in blood binds to proteins at efferent arteriole and causes hyaline atherosclerosis. increases GFR initially, but as BM thickens due to mesangial cells secreting more matrix, GFR reduces
treatment diabetic nephopathy
hypertension, good glycemic control, ACE inhibitors, angiotensin receptor blockers
treatment membranous glomerularnephritis
immunosuppressants
treatment FSGS
steroids
management of nephrotic syndrome
oedema- diuretics
ACE inhibitor to stop lost albumin
treat underlying condition
reduce blood cholesterol
common causes of nephritic syndrome
IgA nephropathy, rapidly progressive GN, Goodpasture’s, post-streptococcal GN
treatment IgA nephropathy
control BP, antihypertensives, steroids
treatment rapidly progressive GN
high dose steroids, immunosuppressants and plasma exchange
treatment goodpastures disease
plasma exchange to remove antibodies, corticosteroids to reduce inflammation
what is rapidly progressive GN
severe glomerular injury causes leakage of fibrin, macrophages and endothelial proliferation. causes cresent shaped masses to form that reduce glomerular blood supply.
what is post streptococal glomerulonephritis
post group a b-haemolytic streptococcus infection of tonsils, pharynx or skin.
treatment post streptococal glomerulonephritis
antibiotics
overall treatment of nephritic syndrome
blood pressure control, oedema treatment, disease specific treatment, CVD risk management, dialysis
