session 2 group work clearance Flashcards
what influences the amount of filtrate produced in the kidney?
the product of the average filtration of each nephron in each kidney
what are the 2 different mechanisms to decrease GFR?
decline in the number of nephrons
decline in the GFR within individual nephrons
in progressive conditions of the kidney why might kidney function not appear to decline until significant kidney damage has occurred?
As individual nephrons can hypertrophy to compensate for the decline in kidney function.
how many litres of blood are filtered a day?
180L/day
what is clearance?
the volume of plasma that is cleared of a substance in a unit of time
what does renal clearance infer?
the kidneys ability to remove a substance from the plasma and excrete in. Gives a good overview on the functioning of the kidney
what are the units of clearance?
mL/min
how do we work out renal clearance?
renal clearance = urine concentration of substance x urine flow rate / plasma concentration of substance
describe the movement of glucose in the kidney
filtered
not secreted
completely reabsorbed
