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Semester 5 - Farmocology > Session 13 - Treatment of Gastric Disease > Flashcards

Session 13 - Treatment of Gastric Disease Flashcards

1
Q

What two ways do you treat GORD and oesophagitis?

A
  • Healing and maintenance

- Treat complications

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2
Q

If a patient presents to GP with GORD, what is the treatment algorithim?

A

Lifestyle -> Antacids -> H2 receptor antagonists -> PPI

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3
Q

If a patient presents to hospital with GORD what are the treatment options?

A

PPI -> H2 Receptor antagonist -> Antacoids

-> Lifestyle modification

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4
Q

Give four adverse reactions of PPI

A

GI upset
Nausea
Headaches
Risk of gastric atrophy

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5
Q

H2 Receptor antagonist

A

Dizziness
Fatigue
Gynaecomsatia
Rash

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6
Q

How do you treat h.pylori infection?

A

PAC
Proton pump inhibitor
Amoxicillin/Clarithromycin
H2 antagonist

For 7-14 days

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7
Q

Name a PPI

A

Omeprazole

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8
Q

Give five indications for PPI

A 
Short term treatment of peptic ulcers
Severe GORD
Confirmed Oesophagitis
Eradication of H.pylori
Zollinger Ellinson Syndrome
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9
Q

What is zollinger ellinson syndrome

A

Gastrin Secreting Pancreatic tumour

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10
Q

What is the mechanism of action of PPI?

A

Irreversibly inhibit Na+/K+ ATPase that are responsible for proton secretion from parietal cells

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11
Q

What are the adverse drug reactions of a PPI?

A

GI upset, nausea
Headaches
Risk of gastric atrophy with long-term treatment

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12
Q

How do PPIs (omeprazole) interact with other drugs?

A

CYP450 Enzyme inhibitor

Avoid use in patients being treated with warfarin, phenytoin

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13
Q

How long does a PPI take to kick in?

A

Action delays as not all pumps are active all the time. Maximum efficacy 2-3 days

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14
Q

How long does it take to reverse effects of PPI?

A

Requires a few days

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15
Q

Name a H2 antagonist

A

Cimetidine

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16
Q

What are two conditions in which H2 antagonist can be used?

A

Peptic ulcer disease

GORD

17
Q

What is the mech of action of H2 antagonist?

A

Competitively antagonise H2 receptors, blocking amplification

18
Q

What are some adverse drug reactions of H2 antagonists?

A

Dizziness
Fatigue
Gynaecomastia
Rash

19
Q

What are some drug drug intercations of H2 antagonists/

A

Cyp450 enzyme inhibitor

Avoid in patients with warfarin or phenytoin

20
Q

What are some therapeutic notes for H2 antagonist?

A

Given at night when acid buffering by food at its lowest

Semester 5 - Farmocology (27 decks)

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