Session 10 - Drugs Rate and Rhythm Flashcards
What is the cardiac resting membrane potential?
-90mV
What sets the resting membrane potential for cardiac cells?
The relative permeability of the cardiac myocyte to K+
What is the equilibrium potential of K+?
-80mV
Outline a contraction of a ventricular myocyte?
o In diastole, the resting membrane potential of cardiac cells is close to the equilibrium potential of K+ (4).
o Initial depolarisation due to spread of electrical activity from pacemaker cells. Once threshold has been reached, fast voltage gated sodium channels are opened, causing depolarisation towards Na+’s equilibrium potential (0).
o Following the rapid depolarisation, a brief repolarisation caused by the outward flow of K+ returns the membrane potential to ~0. (1)
o Na+ channels deactivate, but the depolarisation causes the opening of voltage gated Ca2+ channels, which take longer to activate, keeping the membrane depolarised (2).
o Influx of Ca2+ causes the release of further Ca2+ from cellular stores, causing contraction (See M&R Session 5).
o After ~250ms, Ca2+ channels close.
o Efflux of K+ returns membrane potential to resting (3).
Give the classification of anti-arythmic drugs
Class 1 - Na+ blockes
Class 2 - B blocekrs
Class 3 - K+ channel blockers
Class 4 - Ca2+ channel blockers
Give three types of Na+ channel blockers
1a) Quinidine
1b) Lidocaine
1c) Felcainide
Give a type of beta blocker
Atenolol
Bisoprolol
Metoprolol
Give a widely used K+ channel blocker
Amiodarone
Give a Ca2+ channel blocker
Verapamil
What are the effects of Flecainide and Lidocaine?
Decrease conduction velocity
Increase depolarisation threshold
Decrease automacity
What is the route of administration of flecainide?
Oral and intravenous
What are the indications for flecinaide?
Supraventricular tachyarrythmias (atrial arrhythmia)
Give two contraindications for Flecainide?
Heart failure, History of MI
What is the mechanism of action for Flecainide?
Blocks fast, inward Na+ ion channel (Phase 0)
Give three adverse reactions of flecainide
Dizziness, visual disturbances, arrhythmias
What are the drug-drug interactions for Flecainide?
Metabolised by CYP2D6 and eliminated renally. Inducers/inhibitors
How is lidocaine adminstered?
Intravenously
What are the indications for lidocaine?
Ventricular arrhythmias following MIO
What are the contraindications for Lidocaine (2)
AV block
Heart failure
Give three adverse drug reactions for lidocaine
Hypotension, bradycardia
Nystagmus
Seizures
What do beta blockers act on?
B1 receptors in the heart
What is the action of B blockers
Block sympathetic action
Decrease slop of pacemaker potential in SAN
Decrease chronotrophy
Inhibits adenyl cyclase, decrease inotrophy
What do B blockers do to ventricular action potential?
Shifts it to the right
What are the indications for B blockers? (4)
Angina
Post myocardial infarction
Hypertension
Arrhythmias