Session 1 - Lymphatic system Flashcards

1
Q

What does the lymphatic system consist of?

A
  • Lymphatic capillaries and vessels

* Lymphoid tissues and organs

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2
Q

What is the function of the lymphatic system?

A
  • Innate immunity
  • Adaptive immunity
  • The allergic response
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3
Q

What is the purpose of lymphatic capillaries and vessels?

A

• Fluid moves out of the tissue fluid and blood and needs to be reabsorbed

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4
Q

What are lymphatic capillaries and vessels?

A

• A network of vessels that assist in circulating fluids

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5
Q

What are the functions of lymphatic capillaries and vessels?

A

• Transport excess fluid away from interstitial spaces

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6
Q

How is the lymphatic system different from the CVS?

A

• Lymphatic system moves in a one way direction

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7
Q

Describe the structure of the lymphatic capillaries

A
  • Tiny closed end vessels consisting of simple squamous epithelium
  • More permeable than blood vessels as the lack a basement membrane
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8
Q

Describe the structure of lymphatic vessels

A
  • Resemble small veins

* One way valves

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9
Q

How is lymph pumped around lymphatic vessels

A
  • Contraction of surrounding skeletal muscle
  • Periodic contraction of smooth muscle in lymphatic vessel wall
  • Pressure changes in the chest during breathing
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10
Q

How are lymphatic vessels similar to veins?

A

• One way valves

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11
Q

How are lymphatic vessels different from veins?

A

• No “pump”

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12
Q

What do lymphatic vessels converge and empty into?

A
  • The right lymphatic duct

* The thoracic duct

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13
Q

Where does the right lymphatic duct drain from and where does it empty?

A

• Drains lymph from upper right limb and right half of head, neck and chest, and empties into subclavian vein

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14
Q

Where does the thoracic duct drain from and where does it empty?

A

• Drains from rest of body (other than right lymphatic duct) and empties into left subclavian vein

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15
Q

What are the four lymphoid organs?

A
  • Lymph nodes
  • Tonsils
  • Spleen
  • Thymus gland
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16
Q

What is a lymph node?

A

• Rounded structures, distributed along the lymphatic vessels

17
Q

What is the structure of a lymph node?

A

• Cortex and medulla

18
Q

Describe the cortex of a lymph node

A
  • Outer part

* Follicles with germinal centre, containing dividing lymphocytes

19
Q

Describe the medulla of a lymph node

A
  • Inner part

* Contains phagocytic macrophages

20
Q

What are the 4 lymph nodes which are important clinically?

A
  • Inguinal lymph nodes (groin)
  • Axillary lymph nodes
  • Cervical lymph nodes (neck)
  • Aortic chain lymph nodes
21
Q

What are the three main functions of the lymphatic system?

A
  • Fluid balance
  • Fat absorption
  • Defence
22
Q

How much fluid moves form blood capillaries to intersitial space a day?

23
Q

How many litres of fluid enter lymphatic vessels from blood capillaries?

24
Q

What does the lymphatic system do to fat?

A

• Absorbs it from the digestive tract

25
What is fat absorbed into in the lymphatic system?
• Lacteals (special lymph vessels) located in lining of small intestine. Fat enters lymphatic and then venous circulation
26
What is chyle?
• Lymph that appears milky in appearance due to fat
27
How is the lymphatic system responsible for defence?
* Removal of organisms and foreign substances from the lymph | * Activation of the immune system
28
What lymphadenopathy?
• Collective term for a lymph node enlargement
29
What is lympahdenitis?
• Swollen, painful node responding to foreign antigen
30
How is a lymph node swollen due to cancer different from one swollen by infection?
• Lymph node firm and usually painless
31
What are the tonsils?
• Small masses of lympoid tissue around pharynx
32
What is the function of the tonsils?
• Trap and remove bacteria and other foreign materials
33
What is tonsilitis caused by?
• The congestion of bacteria
34
What is the spleen?
* Largest lymphatic organ | * Contains large amount of circulating blood, due to sinuses
35
What two tissues is the spleen made up of?
• Red pulp and white pulp
36
What is red pulp in the spleen?
* Receives arterial blood which passes into venous sinuses | * Lined by macrophages which removes old red cells and recycles haem
37
What is white pulp in the spleen?
* T and B cell compartments with macrophages and other immune cells * Recognise and remove pathogens * Activates T cells and B cells
38
How does the thymus vary over lifetime?
* Larger in infancy and puberty, before shrinking in adulthood * Replaced by fat and connective tissue in elderly
39
What is the function of the Thymus?
* Site of T lymphocyte production | * Secretes hormones called thymosins