Session 1-Haemodynamics Flashcards
What is the fluid collected from unclotted blood called?
Plasma
What is the fluid collected from clotted blood called?
Serum
What is serum?
Plasma - clotting factors (in particular fibrinogen)
Which cells are in the buffy coat?
WBCs
Platelets
What is peripheral resistance?
Resistance of the arteries to blood flow ie. as arteries constrict, resistance increases and as they dilate, resistance decreases
What is the commonest cause of increase in plasma viscosity and therefore whole blood viscosity?
Multiple myeloma (cancer of plasma cells)
What is the name of the condition caused by an increase in RBCs?
Polycythaemia
What is the name of the condition caused by an increase in platelets?
Thrombocythaemia
What is the name of the condition caused by an increase in WBCs?
Leukaemia
Complete the sentence:
Marked increase in plasma viscosity can lead to _____________ whole blood viscosity and __________ of blood in peripheries.
Increased
Sludging
What can minor changes in plasma viscosity be a result of?
Raised levels of acute phase plasma proteins
Give examples of acute phase plasma proteins
Fibrinogen
Complement factors
C-reactive protein
What do acute phase proteins increase in response to?
Inflammation
True or false: minor changes in plasma viscosity can be used to ‘measure’ the inflammatory response
TRUE
What is the difference between flow and velocity of blood?
Flow is the volume of blood moving per unit time
Velocity is the distance blood travels per unit time