Serotonin site of action

Question 1

mirtazapine (Remeron)

Answer 1

decrease sexual side effects
5HT2 and 5HT3 antagonist and increases 5HT and NE release
SE: sedating but doesnt affect REM

Question 2

trazodone (Desyrel)

Answer 2

safe for cardiac
5HT2 antagonist, 5HT reuptake inhibitor
SE: priapism, sedation

use at night in people on SSRIs

Question 3

nefazodone (Serzone)

Answer 3

less sedating
similar to trazadone but decrease alpha adrenergic antagonism
SE: sedation, constipation