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Pharm > Serotonin Receptors > Flashcards

Serotonin Receptors Flashcards

1
Q

5-HT 1A locations? (3)

A
  • Cortex, hypothalamus

- Raphe nuclei

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2
Q

5-HT 1A effects on cortex, hypothalamus, and raphe nuclei?

A
  • Mood, cognitive function, neuroendocrine function

- Raphe: inhibits 5-HT release

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3
Q

5-HT 1D locations? (2)

A
  • Cerebral vascular smooth m.

- Nerve terminal

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4
Q

5-HT 1D effects on cerebral vascular smooth m. and nerve terminals?

A
  • Vasoconstriction

- Inhibits NT release from nerve terminals (e.g. nociceptive and inflammatory mediators in migraines)

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5
Q

5-HT 2A/2C locations? (2)

A
  • Striatum

- Frontal cortex

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6
Q

5-HT 2A/2C effects on the striatum and frontal cortex?

A

Hallucinations via inhibiting DA release

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7
Q

5-HT 3 locations? (3)

A
  • Enteric chromaffin cells
  • Area postrema
  • Emetic center
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8
Q

5-HT 3 effects on the enteric chromaffin cells, area postrema, and emetic center?

A

Gut motility, N/V

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9
Q

5-HT 4 location? (1)

A

Myenteric plexus (ENS)

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10
Q

5-HT 4 effect on myenteric plexus?

A

Gut motility

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11
Q

5-HT transporter location?

A

5-HT nerve terminals

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12
Q

5-HT transporter effect on 5-HT nerve terminals?

A

Removal of 5-HT from synapse

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13
Q

What 5-HT receptor does buspirone effect, + specific type of agonism/antagonism?
Associated clinical disorders?

A

5-HT 1A partial agonist

- Anxiety, depression

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14
Q

What 5-HT receptor does sumatriptan effect, + specific type of agonism/antagonism?
Associated clinical disorder?

A

5-HT 1D agonist

- Migraine

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15
Q

What 5-HT receptor does trazadone effect, + specific type of agonism/antagonism?
Associated clinical disorders?

What medication is it contraindicated with?

A

SARI; 5-HT 2A/2C antagonist + SSRI (5-HT xporter inhibitor)

- Depression, schizophrenia (contraindicated w/MAO inhibitors)

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16
Q

What 5-HT receptor does ondansetron effect, + specific type of agonism/antagonism?
Associated clinical disorder?

A

5-HT 3 antagonist

- Chemo-induced emesis

17
Q

What 5-HT receptor does mosapride (UK) effect, + specific type of agonism/antagonism?
Associated clinical disorders?
1 serious side-effect? (think)

A

5-HT 4 agonist

  • GI disorders
  • SE: arrhythmia (lengthens QT)
18
Q

What 5-HT receptor does fluoxetine/sertraline effect, + specific type of agonism/antagonism?
Associated clinical disorders?

W/what medication are they contraindicated?

A

5-HT transporter inhibitor
- Depression, panic disorder, OCD, PTSD, social phobia

Contraindicated w/MAO inhibitors (Serotonin syndrome)

19
Q

What 5-HT receptor does risperidone effect, + specific type of agonism/antagonism?
Associated clinical disorders?
*Which 2 DA pw’s does it affect and how?

A

2nd gen anti-psychotic: 5-HT 2A + D 2/3 antagonist

  • Schizophrenia w/psychosis
  • Suppresses DA release in mesolimbic pw (reduce psychosis via D 2/3), increases DA release in mesocortical pw (reduce hallucinations via 5-HT 2A)
20
Q

What receptor does L-DOPA effect, + specific type of agonism/antagonism?
Associated clinical disorder?

Serious side effects?

A

D 1/2 receptor agonist (increases DA in nigrostriatal pw)
- PD

SE: Arrhythmia, dyskinesia

21
Q

What enzyme does carbidopa effect? Positively or negatively?

Associated clinical disorder?

A 
Targets AADC (makes DA from L-DOPA) in peripheral tissues
- PD
22
Q

What receptor does bromocriptine effect, + specific type of agonism/antagonism?
Associated clinical disorder?

A

D 2/3 receptor agonist

- PD

23
Q

What receptor does selegiline effect, + specific type of agonism/antagonism?
Associated clinical disorder?

Serious side effects?
Contraindicated w/what medication?

A

MAO-B selective antagonist
- PD (early)

SE: Hypotension, hypertensive crisis
- Sympathomimetics

24
Q

What enzyme does tolcapone effect? Positively or negatively?
Associated clinical disorder?

Contraindicated w/what dz?

A

Inhibits COMT
- PD (advanced)

Liver failure

25
Q

What receptor does haloperidol effect, + specific type of agonism/antagonism?
Associated clinical disorder?

A

D2 antagonist

- Psychosis

26
Q

What receptor does metaclopramide effect, + specific type of agonism/antagonism?
Associated clinical disorder?

Major side effects?

A

D2 antagonist + 5-HT 4 agonist properties
- Nausea

SE: akathisia, focal dystonia

Pharm (32 decks)

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