Serotonin And Migrain

Question 1

H1-R, 5HT2-R antagoist that used in smooth muscle manifestation of carcinoid tumor, in the postgastrectomy dumping syndrome, cold induced utricaria, OTC appetizer

Answer 1

Cyproheptadine

Question 2

5 HT2C agonist used for weight-loss medication

Answer 2

Lorcaserin

Question 3

5HT3-R antagonist used as anti-emetic in vomiting due to cancer chemotherapy

Answer 3

Ondansetron

Question 4

5-HT2-R functions

Answer 4

Depression, platelets aggregation
Smooth M F contraction
Perstaltic movement
VC of all B.V except S.M B.V

Question 5

5-HT3-R functions

Answer 5

Vomiting center
GIT:Enteric nervous system
Regulation of motility

Question 6

5HT1-R functions

Answer 6

Sleep, appetite, temp.regulation, thinking, cognitive function
V.C

Question 7

5-HT1D/1B Agonist used in migrain to VC of cerebral BV

Answer 7

Tryptan(sumatriptan)

Question 8

5-HT1A Agonist used in anxiety

Non benzodiazepine

Answer 8

Buspirone

Question 9

HT4-R functions

Answer 9

CNS
GIT: Enteric NS, Inflammatory bowel syndrome, (IBS), chronic constipation
Cardiac muscle : arrythmia

Question 10

5-HT4 partial agonist used in irritable bowel syndrome with constipation

Answer 10

Tegaserod

Question 11

5HT4-R Agonist used in treatment of gastroesophageal reflux and motility disorder

Answer 11

Cisapride

Question 12

5-HT6,7 Functions:

Answer 12

CNS:Cognition

Question 13

5HT7-R Antagonist used in Psychosis, Pschizophrenia

Answer 13

Clozapine

Question 14

Selective serotonin reuptake inhibitor (SSRI) Used in depression

Answer 14

Fluoxetine

Question 15

Drug can deplete stored serotonin

Answer 15

Reserpine

Question 16

Alpha Adrenoceptor antagonist and has long-lasting blocking action at 5-HT2 receptors

Answer 16

Phenoxybenzamine