NSAIDs Flashcards
What are the NSAIDs?
They are heterogeneous group having anti-inflammatory, analgesic and antipyretic effects.
Prototype NSAID:
Aspirin
Non selective NSAIDs:
ibuprofen, naproxen, diclofenac, piroxicam and indomethacin.
Selective Cox-2 inhibitor:
Celecoxib
Analgesic-antipyretic with weak anti-inflammatory action:
Paracetamol
Mainly constitutive Cyclooxygenase enzyme that respnsible for forming protevtive PGs in GIT and kidney
Cox-1
Cox Inducible in inflammation, constitutive in endothelium and kidney:
Cox-2
Mechanism of aspirin:
Aspirin ireversibly inhibits (acetylates) cyclooxygenase enzymes (cox1, cox2)》inhibit PG and TXA2 production.
Paracetamol mechanism:
It inhibits PG synthesis mainly in CNS
May act on cox3 (weak anti-inflammatory effect
Its action may involve interaction with the serotonergic and endogenous opioid system
The NSAIDs lower body temp in patients with fever by :
Blocking PGE2 synthesis and release.
NSAIDs have no effect on normal body temp..
True
PGE2 pain mechanism:
It is throught to sensitize nerve endings to the action of bradykinin, and histamine
NSAIDs in pain:
They are mainly for management of pain of low to moderate intensity arising from musculoskeletal disorders rather than that arising from viscera
Advantages over opioid analgesics:
No dependence, no respiratory depression in theraputic doses
Anti-inflammatory action of NSAIDs
– leukocyte migration and – release of lysosmal enzymes.
They inhibit inflammation in arthritis, but they neither arrest the progress of the disease nor induce remission
