Serotonin

Question 1

Involved in:

Answer 1

Food intake, sexual behaviour, pain, anxiety, learning, memory, mood, sleep, cognition

Question 2

Synthesis pathway

Answer 2

Tryptophan converted into 5-HTP by tryptophan hydroxylase (rate limiting step), 5-HTP converted to 5-HT by aromatic L-amino acid decarboxylase

Question 3

Tryptophan hydroxylase

Answer 3

2 forms, 1+2. 1=non neuronal cells 2= neurons

Use immunohistocytochemistry to locate serotonergic neurons

Question 4

Parachlorophenylalanine

Answer 4

Inhibits TH 1+2; blocks 5-HT synthesis

Question 5

Reserpine

Answer 5

Inhibits VMAT2 transporters

Question 6

Fenfluramine

Answer 6

Release 5-HT from neurons

Question 7

MDMA

Answer 7

Release 5-HT from neuron

Question 8

SSRI

Answer 8

Inhibits reuptake of serotonin (selective)

Question 9

Cocaine

Answer 9

Inhibits reuptake of serotonin and NE

Question 10

Monoamine oxidase

Answer 10

Breaks down 5-HT

Question 11

5-HIAA

Answer 11

5-HT metabolite; Low concentrations in CSF associated with suicidal behaviour

Question 12

Buspirone

Answer 12

Agonist of 5-HTR1a, decreases food intake and anxiety

Question 13

Locations

Answer 13

Gut, CNS