Serologic Tests For Syphilis Flashcards

1
Q

A protein found in most treponemes both saprophytic and pathogenic.

A

Common antigen

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2
Q

Restricted to one species

A

Specific Antigen

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3
Q

About 90% of infected are seropositive by what week of infection?

A

3rd week

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4
Q

The primary stage of syphilis is associated with a lesion called ______.

A

Chancre

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5
Q

Originally a liver intract from fetuses with congenital syphilis that contained large numbers of treponemes. This antigen was later found to be present in normal liver and other tissues, especially cardiac muscle.

A

The Wassermann antigen

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6
Q

A rash occurs 6-8 weeks after the appearance of w chancre

A

Secondary stage

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7
Q

Period where clinical signs and symptoms are absent but antibody will be present. The infectd individual usually isn’t contagious and transmission is restricted to rare cases between mother and fetus

A

Latent period

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8
Q

No symptoms but serology test remain positive

A

Latent period

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9
Q

Lesions appear 3-10 or more years after the primary stage

A

Tertiary stage

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10
Q

_________ is a non-specific, non-treponemal antibody found in infections caused by T. palladium

A

Reagin (anti-cardiolipin)

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11
Q

The reaction between reagin and cardiolipin is manifested as clumping to form visible masses and is known as a process called _________

A

Flocculation

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12
Q

Biological false positives can be caused by:

A

Febrile illnesses
Chronic diseases
Autoimmune diseases

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13
Q

Two types of reagin tests

A

VDRL (veneral disease research laboratory)

RPR (rapid plasma reagin)

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14
Q

Detects reagin in serum and CSF

A

VDRL

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15
Q

Uses a suspension of specially prepared charcoal particles to allow macroscopic reading and allows the plasma to be tested without preliminary heating.

A

Rapid plasma reagin

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16
Q

An antibody distinct from reagin that inhibits the normal movement of pathogenic treponemes of syphilis in the presence of complement

A

Principle