Immune Deficiencies And Laborstory Diagnosis Flashcards
Genetic anomalies of various components of the immune system
Congenital or primary immune deficiency
When the immune system is normal at birth and a defect occurs at a later time, can be induced by a wide variety of processes: infections, neoplasms, irradiation, chemotherapy, or corticosteroids
Acquired or secondary immune deficiency
Primarily a T-cell dysfunction resulting from increased susceptibility to viral fungal infections
Cellular immune deficiency
Primarily a B-cells that are impaired resulting in increased susceptibility to bacteria infections
Humoral immune deficiency
A condition in which the development defect is at the level of the stem cell
Reticular dysgenesis
An inherited defect affecting the lymphoid precursor so there are markedly reduced lymphocytes and virtually no antibody production.
Severe combined immunodeficiency (SCID)
This condition is caused by the deterioration of the thymus and is marked by a decreased number and function of T-cells, serum levels of Ig M are low but exhibit normal to increased numbers of other antibodies, and a decreased platelet count and eczema.
Wiskott aldrich syndrome
Condition caused by insufficient thymic tissue (thymic hypoplasia) due to abnormal development in the embryo marked by deficiency in the number/function T-cell, normal levels of immunoglobulin and B-cells
Digeorge’s syndrome
Know as X-linked agammaglobulinemia or x-linked hypogammaglobulinemia and is an inherited congenital disease characterized by a severe deficiency of B lymphocytes and is a predisposing factor for bacterial infections
Brutons agammaglobulinemia
Infection leading to a selective depletion of t lymphocytes
Human immunodeficiency virus
Failure to respond to an antigen
Anergy
Delayed type hypersensitivity skin test used to evaluate the cellular immune response to intradermally injected antigen.
T-cell function
PHA and Con A preferentially stimulates which type of cell?
T lymphocytes
PWM stimulates both ____ and ____ cells
T
B
Evaluation of overall antibody levels in serum by the separation of Serum proteins using an electric charge
Electrophoresis
