Complement Flashcards
Target cells include
Leukocytes
Erythrocytes
Thrombocytes
Gram negative bacteria
Cells resistant to complement-mediated cytolysis
Fungi, most plant cells, many gram positive bacteria, and most mammalian cells
Complement activity is destroyed by heating serum to ________ for 30 minutes.
56 degrees Celsius
Two compliment fixing antibodies
Ig G and Ig M
The activation of complement
Complement cascade
Set of plasma proteins and plays a major role in lysis of cellular antigens in conjunction with specific antibodies
Complex
Comment fixing Ab’s
Ig M and Ig G
Physiologic functions of compliment
Chemotaxis Opsonization Anaphyltoxin formation Virus neutralization Immune adherence
In classical pathways activation of Ag Ab complexes involve what two immunoglobulins?
Ig M and Ig G
Alternate pathway activation is initiated by _________.
Complex polysaccharides or enzymes
How many components are required for activation in classical pathways?
9
How man components are required for activation in alternate pathways?
6
C1,as a part of the complement cascade, is also known as the ______ unit.
Recognition unit.
Enzymatic activation involves components ___, ___, and _____.
C4
C2
C3
Membrane attack involves ____ to ____ resulting in cytolysis of cellular antigens.
C5
C9
This component of the classical pathways is a pentamolecular complex held together by calcium ions
C1
A subunit of C1 that acts as the recognition unit that binds to the Fc region of Ig G (then Ch2 domain) and Ig M ( the Ch4 domain)
C1q
The attachment of C2b and C4b fragment creates C42b also known as ______.
C3 convertase.
Classical pathway activation sequence
C1- removal of calcium ions dislocates into C1q, C1r, and C1s C1q is initiated by binding to Fc receptors on Ig G and Ig M antigen sites C4 C2 C3 C5 C6 C7 C8 C9
