Complement

Question 1

Target cells include

Answer 1

Leukocytes
Erythrocytes
Thrombocytes
Gram negative bacteria

Question 2

Cells resistant to complement-mediated cytolysis

Answer 2

Fungi, most plant cells, many gram positive bacteria, and most mammalian cells

Question 3

Complement activity is destroyed by heating serum to ________ for 30 minutes.

Answer 3

56 degrees Celsius

Question 4

Two compliment fixing antibodies

Answer 4

Ig G and Ig M

Question 5

The activation of complement

Answer 5

Complement cascade

Question 6

Set of plasma proteins and plays a major role in lysis of cellular antigens in conjunction with specific antibodies

Answer 6

Complex

Question 7

Comment fixing Ab’s

Answer 7

Ig M and Ig G

Question 8

Physiologic functions of compliment

Answer 8

Chemotaxis
Opsonization 
Anaphyltoxin formation 
Virus neutralization 
Immune adherence

Question 9

In classical pathways activation of Ag Ab complexes involve what two immunoglobulins?

Answer 9

Ig M and Ig G

Question 10

Alternate pathway activation is initiated by _________.

Answer 10

Complex polysaccharides or enzymes

Question 11

How many components are required for activation in classical pathways?

Answer 11

9

Question 12

How man components are required for activation in alternate pathways?

Answer 12

6

Question 13

C1,as a part of the complement cascade, is also known as the ______ unit.

Answer 13

Recognition unit.

Question 14

Enzymatic activation involves components ___, ___, and _____.

Answer 14

C4
C2
C3

Question 15

Membrane attack involves ____ to ____ resulting in cytolysis of cellular antigens.

Answer 15

C5

C9

Question 16

This component of the classical pathways is a pentamolecular complex held together by calcium ions

Answer 16

C1

Question 17

A subunit of C1 that acts as the recognition unit that binds to the Fc region of Ig G (then Ch2 domain) and Ig M ( the Ch4 domain)

Answer 17

C1q

Question 18

The attachment of C2b and C4b fragment creates C42b also known as ______.

Answer 18

C3 convertase.

Question 19

Classical pathway activation sequence

Answer 19

C1- removal of calcium ions dislocates into C1q, C1r, and C1s
C1q is initiated by binding to Fc receptors on Ig G and Ig M antigen sites
C4
C2
C3
C5
C6
C7
C8
C9