Sepsis Summary Lecture

Question 1

how effective are antibiotics in pus forming infections (quinsy, abscess etc)?

Answer 1

antibiotics don’t reach pus

need surgery/drainage

Question 2

general rule for surgical prophylaxis?

Answer 2

24 hrs duration

single dose

Question 3

what cultures are needed in endocarditis?

Answer 3

3 blood cultures within the hour before antibiotics

Question 4

how many cultures are needed for sepsis?

Answer 4

1?

before/after antibiotics?

Question 5

gentamicin is inactive against what?

Answer 5

anaerobes

Question 6

vancomycin is only active against what?

Answer 6

gram +ves

Question 7

gentamicin only covers what?

Answer 7

gram -ves

Question 8

cephtazidime is what type of antibiotic?

Answer 8

cephlasporin

Question 9

is aztreonam safe in penicillin allergy?

Answer 9

yes

even though it is a beta lactam

Question 10

which antibiotic is used for staph aureus blood infection?

Answer 10

IV flucloxacillin

Question 11

which antibiotic is used for staph aureus blood infection is penicillin allergic?

Answer 11

IV vancomycin

Question 12

how long are you on antibiotics after sepsis?

Answer 12

6 weeks

Question 13

how much IV saline is initially given to patients with sepsis?

Answer 13

500ml bolus

Question 14

mortality of septic shock?

Answer 14

> 40%

Question 15

most likely cause of infection in gut/biliary system?

Answer 15

coliforms

anaerobes

Question 16

initial and step down therapy for sepsis with gut/biliary origin?

Answer 16

amox, met and gent

step down to co-trimoxazole and metranidazole

Question 17

prevalence of type 1 penicillin allergy?

Answer 17

<0.5%

Question 18

which antibiotic is used in ESBL infection?

Answer 18

meropenem