Sepsis

Question 1

Definition

Answer 1

Life threatening organ dysfunction due to a disproportionate systemic inflammatory response to an host infection.

Question 2

Pathophysiology

Answer 2

A pathogen causes stimulation of the immune system which creates cytokins.
Cytokins release sytoxic chemicals to kill the pathogens which also can cause endothelial damage.

Question 3

Three physiological sepsis reactions

Answer 3

Coagulopathy- vascular thrombosis and suppression of platlets.
Hypotension- Cytonkins dilating the blood vessels.
Endothelium widespread destruction. Higher permeability

Question 4

SIRS

Answer 4

Tachycardia- above 90bpm 
Altered mental state 
Pyrexia 38 degrees 
Hypothermia 36 degrees 
Hyperventilation above 20 
Blood glucose above 7.7 without diabetes

Question 5

Quick SOFA

Answer 5

Altered Mental state
Hypotension systolic 90 or below
Hyperventilation 22 or above

Question 6

Sepsis red flags

Answer 6

Tachcardiya 130 
BP 90 
Sats 91 
resps above 25
AVPU
Lactate above 2-4

Question 7

Sepsis 6

Answer 7

Going in Oxygen (Blood gas)
Broad spec antibiotic
IV fluids crystaloids

Going Out 
Lactate
Blood Cultures 
Bloods- FBC, UNE'S LFTS CRP 
Fluid Balance

Question 8

Causes of infections

Answer 8

Strep A
Strep B
PROM
influenza