Sepsis

Question 1

What is the definition of SIRS?

Answer 1

Systemic Inflammatory Response Syndrome
Pyrexia or low temp
Tachycardia
Tachypnoeic
Reduced PaCO2
High WBC

Question 2

What is the difference between sepsis and septic shock?

Answer 2

Sepsis is SIRS and infection

Septic shock is sepsis plus hypotension

Question 3

What is the definition of sepsis?

Answer 3

Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host response to infection

Question 4

What does a SOFA score of over 2 mean?

Answer 4

Indicates a mortality rate of 10%

Question 5

What is the definition of septic shock?

Answer 5

Septic shock can be identified with a clinical construct of sepsis with persisting hypotension requiring vasopressors to maintain MAP >65mmHg and having a serum lactate of >2mmol/l despite adequate volume resuscitation

Question 6

What does the SOFA score mean?

Answer 6

Sequential Organ Failure Assessment score

Use resp info, coagulation, GCS, renal function, liver function and MAP.

Question 7

What is used for the qSOFA?

Answer 7

Low BP
Altered mental state
Tachypnoeic
A score of two or more indicates a poor outcome

Question 8

What will be seen on investigations in sepsis?

Answer 8

Raised CRP
Raised WCC or low WCC
Raised procalcitonin
High lactate
Raised venous oxygen pressure
Thrombocytopenia
Hyperbilirubinemia

Question 9

What are the two types of lactate?

Answer 9

Type A - Hypoperfusion

Type B – Mitochondrial toxins, Alcohol, Malignancy, metabolism errors