Seminar 2 - slides content

Question 1

p14 gene function?

Answer 1

MDM2 inhibitor

Tumor profile: colon, stomach and kidney
Results in degradation of p53

Question 2

hMLH1 gene function?

Answer 2

DNA mismatch repair

Tumor profile: in colon, endometrium and stomach
Results in frame shift mutations

Question 3

BRCA1 gene function?

Answer 3

DNA repair and transcription

Tumor profile:breast and ovary
Results in Double strand breakage

Question 4

p73 gene function?

Answer 4

p53 homologoue

Tumor profile: lymphoma

Question 5

DAPK gene function?

Answer 5

Pro-apoptotic

Tumor profile: lymphoma, lung , Colin
Results in resistance to apoptosis

Question 6

TMS1 gene function?

Answer 6

Pro-apoptotic

Tumor profile: breast,
Results in resistance to apoptosis

Question 7

p16 gene function?

Answer 7

CDK Inhibitor

Results in entrance in cell cycle

Question 8

p15 gene function?

Answer 8

Cyclin dependant kinase inhibitor

Tumor profile: leukemia
Results in entrance in cell cycle

Question 9

MGMT gene function?

Answer 9

DNA repair of 06-alkyl-guanine

Results in mutations and chemosensitivity

Question 10

Karyotype?

Answer 10

Ordered display of an individual’s chromosomes

Collections of chromosomes from mitosis cells

Question 11

Protiens stored in nucleolus?

Answer 11

Nucleolin- regulates transcription

Fibrilarin- forms snRNP

Telomerase- not active when bound to nucleolus

Nucleostemin- binds p53 and renders it inactive

Question 12

NOR function?

Answer 12

Is present of short arms of ch, 13, 14, 15, 21 and 22

And allows the formation of nucleolus after cell division

Question 13

RNA interference

Answer 13

Process of binding and neutralizing mRNA

These are single stranded molecules of RNA which perform this process