Chapter 18- The Cell Division Cycle (Apoptosis Part)

Question 1

The swelling of cell as a result of acute injury is called

Answer 1

Necrosis

Question 2

What happens when a cell undergoes apoptosis?

Answer 2

• the cytoskeleton collapses
• nuclear envelope disassembles
• nuclear DNA breaks up into fragments

Question 3

The machinery of apoptosis involves which proteins?

Answer 3

Caspases

Note: these belong to family of proteases the members of which are made as inactive precursors called as “procaspases”

Question 4

What proteins are responsible for activation of procaspases ?

Answer 4

Proteins of Bc12 family

Question 5

What family of Bc12 protein promote procaspase activation and cell death?

Answer 5

bax & bak
Note: these proteins activate procaspase indirectly by inducing the release of cytochrome c from the mitochondria
- This cytochrome C promotes assembly of a large seven armed pinwheel like structure called as “apoptosome”
- Procaspase molecule become activated into apoptosome triggering a caspase cascade leading to death of cell

Question 6

Programmed cell death?

Answer 6

Apoptosis