Self - antigen and disease Flashcards

1
Q

TSH receptor

A

Hyper/ Hypo thyroid

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2
Q

Insulin receptor

A

Hyper/Hypo glycaemia

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3
Q

ACH receptor

A

Myasthenia gravis

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4
Q

Epidermal cell adhesion molecules

A

Blistering skin diseases

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5
Q

Factor VIII

A

Acquired haemophilia

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6
Q

Beta-2 glycoprotein and other anticoagulant proteins

A

Antiphospolipid syndrome

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7
Q

Red blood cells

A

Haemolytic anaemia

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8
Q

Platelets

A

Thrombocytopenic purpura

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9
Q

thyroid peroxidase

A

Thyroditis, hypothyroidism

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10
Q

Steroid 21- hydroxylase

A

Adddisons disease

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11
Q

Glutamate decarboxylase

A

Diabetes 1

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12
Q

Lysosomal enzymes (phagocytic cells)

A

Systemic vasculitis

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13
Q

Mitochondrial enzymes (particularly pyruvate dyherdrogenase)

A

Primary biliary cirrhosis

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14
Q

Double-stranded DNA

A

SLE

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15
Q

Histones

A

SLE

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16
Q

Topoisomerase I

A

Diffuse scleroderma

17
Q

Amino-acyl-T-RNA synthases

A

Polymyositis

18
Q

Centromere proteins

A

Limited scleroderma