Seizures

Question 1

GABA and its effects on the brain

Answer 1

• inhibitory neurotransmitter because it blocks, or inhibits certain brain signals and decreases activity in your nervous system. When GABA attaches to a protein in your brain known as a GABA receptor it produces a calming effect/

Question 2

Increasing the stimulation of GABA receptors (used for absence seizures)

Answer 2

increases activity of GABA receptor, reducing excitability of post synaptic neurons and increasing seizure threshold.

Question 3

Reduce Na+ influx to neurons (tonic clonic and partial, absence)

Answer 3

desensitize Na+ channels thereby delaying opening of channels and reducing excitability of neurons

Question 4

Seizures

Answer 4

Disturbance of the brain’s electrical activity that may affect consciousness, motor activity and sensation\

Question 5

Reduce Ca2+ influx to neurons

Answer 5

calcium is necessary for neural transmission. Succinomides block calcium channels delyaing caclium entry and raising the seizure threshold. indicated primarily for absence seizures

Question 6

Medication used to treat every kind of seizure except absence?

Answer 6

Phenytoin - reduces Na+ influx to neuron.

- provide seizure suppression without CNS depression.

Question 7

What to monitor when giving Phenytoin

Answer 7

• has very narrow range between therapeutic dose and toxic dose. clients must be closely monitored for toxicity. if blood test result . 80 do not five.

Question 8

Four types of generalized onset seizures

Answer 8

• Tonic - clonic (aura)
• absence (non-motor)
• atonic (really brief)
• Myoclonic (motor) - not Loss of consciousness

Question 9

Partial onset seizures

Answer 9

• simple (aware)

- complex (impaired awareness)

Question 10

Gabapentin

Answer 10

How does it work? – structurally related to GABA, but does not interact with the receptors themselves. Inhibits calcium channels from opening.
What is it used for? - nerve pain, increases seizure threshold and decrease the incidence of seizure. Prevents chronic pain pathways from forming
Common side effects:
CNS depression, dizziness, drowsiness, dry mouth