Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BPS > Segars: Antipsychotics > Flashcards

Segars: Antipsychotics Flashcards

1
Q

Which drug is good for recurrent suicidal behavior?

A

-Clozapine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Positive sx of schizophrenia

A
  • hallucinations, delusions, disorganized speech/thinking, agitation, abnormal motor behavior
  • meso-limbic pathway
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the main difference between agent-groups?

A

-reduction in movement-disorder SE’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the 2 kinds of antipsychotics?

A
  • First gen

- second gen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

First Generation agents (typical)

A
  • Choropromazine
  • fluphenazine
  • haloperidol
  • Thioridazine
  • Thiothixene
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Second generation agents (atypical)

A

-Aripiprazole
-clozapine
-olanzapine
-quetiapine
=risperidone
=ziprasidone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Negative sx for schizo

A
  • apathy, avolition, alogia, cognitive deficits, social withdrawal
  • mesocortical pathway
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What does dopamine inhibit?

A
  • prolactin release

- tuberoinfundibular pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Which brain pathways are associated with side effects?

A

-Nigrostriatal pathway and the EPS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

what do first gen antipsychotics do?

A

-block DA type 2 (D2) post synaptic receptors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what other receptors do FGA’s bind to?

A
  • muscarinic
  • Histamin
  • alpha adrenergic receptors
  • D2 receptors
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Muscarinic FGA SE’s

A
  • dry mouth
  • cant poo
  • cant pee
  • blurred vision
  • sedation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Alpha adrenergic effects of FGA’s

A

-orhtostatic hypotension
-dizziness/syncope
-

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Histamine effects for FGA’s

A

-sedation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What does dopamine affect?

A

-hyperprolactinemia

=extrapyramidal sx (like parkinsonism)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Tx for extrapyramidal sx

A

-anticholinergic agents
-Diphenhydramine
=beztropine
=trihexyphenidyl

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What does High D2 occupancy lead to?

A

-High EPS risk

18
Q

What 2 categories do we divide the FGA’s into?

A
  • Low potency: chlorpromazine
  • thioridazine
  • high potency
  • High potency:
  • Fluphenazine
  • Haloperidol
  • Thiothixene
19
Q

What doe SGA’s do?

A
  • block D2 receptors and also 5HT2A

- stronger for serotonin

20
Q

What is the D2 partial agonist?

A
  • Aripiprazole

- aiding in dysregulation in the mesocortical pathway

21
Q

what is clozapine only reserved for?

A

-recurrent suicidal effects

22
Q

SGA SE’s

A
  • weight gain

- metabolic effects: hyperglycemia/insulin resistance, hyperlipidemia

23
Q

Which drugs will give you weight gain and diabetes?

A
  • the SGA’s!
  • Clozapine
  • olanzapine
  • but aripiprazole and ziprasidone are good
24
Q

Which drugs will give us hypercholesterolemia

A
  • clozapine

- olanzapine

25
Q

Which first gen drug had a lot os +’s

A

-Chorpromazine

26
Q

Which drug will give us EPS/ tardive dyskinesia?

A

-haloperidol

27
Q

Which drug will give us prolactin elevation?

A

-the FGA’s!

28
Q

Which drugs will give us sedation?

A
  • Chlorpromazine
  • Thioridazine
  • clozapine (the suicide question is the only one when this will be the answer)
  • Quetipaine (quieting the patient lol)
29
Q

Which drugs are the really good ones generally?

A
  • Aripiprazole

- ziprasidone

30
Q

Which drugs will give us Anticholinergic SE’s

A
  • Chlorpromazine
  • Thioridazine
  • Clozapine
31
Q

Which drug will give us QT prolongation

A

-Thioridazine

32
Q

rare but severe SE for Clozapine

A

-agranulocytosis

33
Q

Which drug will give us a drug reaction w/ eosinophilia and systemic sx?

A

-olanzapine

34
Q

What is the tx for Neuoleptic malignant syndrome?

A
  • dantrolene

- blocks RyR

35
Q

What is the baseline antipsychotic monitoring we want to do?

A
  • Medical and gamily hx including CV disease
  • Weight
  • Waist circumference
  • Blood Pressure
  • Fasting glc
  • fasting lipid
36
Q

Which agents are more commonly recommended and utilized as first line, initial therapy?

A

-the atypical agents

37
Q

What is critical?

A
  • adherence
  • non adherence can be managed with long acting jecectable agents
  • ROAP
  • Risperidone
  • olanzapine
  • aripiprazole
  • Paliperidone palmitiate
38
Q

Does antipsychotic tx take long?

A

-yes, god yes

39
Q

What drug do we give for multi drug resistance or suicidal thoughts?

A

-clozapine

40
Q

Which agents are known for having EPS related SE’s?

A
  • First Gen!

- Haloperidol

41
Q

Easy way to remember the SGA’s?

A

-the ending “apine”

BPS (15 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions