Sedative Hypnotics Flashcards
1
Q
Types of Sedative Hypnotics
A
Benzodiazepines (diazepam, flurazepam)
Barbiturates (phenobarbital, secobarbital)
Other agents (ethanol, chloral hydrate)
Over-the-counter agents (antihistamines)
2
Q
What are major points in the graded depression of the reticular activating system (arousal/sleep-awake cycle)?
A
Low dose -anti-anxiety -sedation -hypnosis -anesthesia High dose
3
Q
When were barbiturates first synthesized?
A
1864
4
Q
When were benzodiazepines first synthesized?
A
1930
5
Q
Points of administration/absorption
A
- produces CNS depression
- readily absorbed from digestive tract
- different preparations available with different lipid solubilities
- highly lipid soluble