Cocaine Flashcards
1
Q
How is cocaine distributed in the body?
A
Penetrates brain, easily crosses placenta
2
Q
Does alcohol effect the action of cocaine? If so, how?
A
cocaine + alcohol = cocaethylene metabolite (pharmacologically active metabolite)
3
Q
How is cocaine metabolized/excreted?
A
half life of 50 mins
-removed by enzymes in liver and plasma
major metabolite benzoylecgonine
4
Q
What are the three major points of cocaine’s mechanism of action?
A
- potent local anesthetic
- vasoconstrictor (raises BP by constricting blood vessels)
- powerful psychostimulant - strong reinforcing effects
