Section 1 Flashcards
Anatomy and Neurology
All of the following are characteristics of Wallenberg’s syndrome, except
A. Ipsilateral Homer’s syndrome
B. Vertebral artery ocdusion
C. lpsilateral decreased pain and temperature in the body
D. Ipsilateral ataxia
E. lpsilateral decreased pain and temperature in the face
C. lpsilateral decreased pain and temperature in
the body
Wallenberg’s (lateral medullary) syndrome is
caused by vertebral a or PICA (posterior inferior
cerebellar artery) occlusion. The clinical picture is
ipsilateral except for pain and temperature in the
body, which is contralateral (ventral and lateral
spinothalamic tracts).
Antibodies to presynaptic voltage-gated ca++ channels (VGCC), in patients with oat cell lung carcinoma are associated with
A. Stiff-man syndrome
B. Lambert-Eaton myasthenic syndrome
C. Myasthenia gravis
D. Anti-Hu antibodies
E. Anti-Yo antibodies
B. Lambert-Eaton myasthenic syndrome
Lambert-Eaton myasthenic syndrome is characterized by antibodies to presynaptic voltage-gated Ca++ channels (VGCC). Myasthenia gravis is caused by antibodies to nicotinic AChR (acetylcholine receptors) or MuSK (muscle-specific kinase). Anti-Hu is associated with lung cancer (oat cell carcinoma) and lymphoma. Anti-Yo is associated with ovarian and breast cancer. Stiff-man (Moersch-Woltman) (Stiff-person) syndrome is related to anti-GAD (glutamic add decarboxylase) is non-paraneoplastic, or anti-amphiphysin or anti-gephyrin which are paraneoplastic.
Struthers ligament is associated with entrapment of
A. Median n at the elbow
B. Median n at the wrist
C. Ulnar n at the elbow
D. Ulnar n at the wrist
E. Radial n
A. Median n at the elbow
The ligament of Struthers can attach to a medial
supracondylar process of the humerus and cause
entrapment of the median n proximal to the elbow
joint. The arcade of Struthers (controversial) can be
associated with ulnar n entrapment at the elbow
and may cause recurrence after decompression.
The posterior interosseous n (PIN), a branch of the
radial nerve can be entrapped under the arcade of
Frohse.
A 65-year-old male had transient aphasia and was found to have 75% ICA stenosis. The ideal treatment is
A. Observation and treatment of risk factors
B. Daily Aspirin 81 mg
C. Daily Aspirin 325 mg
D. IV heparin followed by oral Coumadin
E. Carotid endarterectomy
E. Carotid endarterectomy
According to NASCET (North American Carotid
Endarterectomy Trial), carotid endarterectomy
reduces the risk of stroke for symptomatic carotid
artery stenosis of >70%, from 26% to 9% at 2 years.
The yearly risk of rupture of cerebral AVM is
A. 0-1%
B. 1-2%
C. 2-4%
D. 4-6%
E. 6-8%
C. 2-4%
The annual risk of rupture of cavemomas is
0.5-1%, aneurysms 1-2%, and AVMs 2-4%.
All of the following statements are true regarding the cerebellar climbing fibers, except
A. They arise in the contralateral inferior olivary nucleus
B. They traverse the inferior cerebellar peduncle
C. They climb to the molecular layer
D. They synapse with the stellate and basket cells
E. They inhibit Purkinje cells
E. They inhibit Purkinje cells
The climbing (olivocerebellar) fibers are excitatory secreting glutamate. Also, mossy fibers and granule cells are excitatory. Purkinje cells are inhibitory.
What is the typical location for endoscopic third ventriculostomy (E1V)?
A. Anterior to the optic chiasm
B. Between the chiasm and the pituitary infundibulum
C. Between the median eminence and the mammillary bodies
D. just posterior to the mammillary bodies
E. None of the above
C. Between the median eminence and the mammillary bodies
Endoscopic third ventriculostomy is performed
in the floor of the third ventricle between the
Mammillary bodies and the Median eminence.
The most common location for a saccular brain aneurysm is
A. Anterior communicating a (ACOM)
B. Posterior communicating a (PCOM)
C. Middle cerebral a (MCA)
D. Basilar a tip
E. Posterior inferior cerebellar a (PICA)
A. Anterior communicating a (ACOM)
Incidence of saccular aneurysms of the brain:
ACOM:40%
PCOM:30%
MCA: 20%
Basilar: 8%
PICA: 2%
A 25-year-old male presents with daily unilateral headache associated with rhinorrhea, lacrimation, and conjunctival injection. The most likely diagnosis is
A. Classic migraine
B. Migraine variant
C. Tension headache
D. Cluster headache
E. Pseudotumor cerebri
D. Cluster headache
Typical description of cluster headache: young adult male, unilateral headache, parasympathetic discharge causing lacrimation, rhinorrhea, and conjunctival injection. It occurs every day for weeks to months.
In the following diagram the thalamostriate v is labeled
A. 1
B. 2
c. 3
D. 4
E. 5
B. 2
- Septal v, 2. thalamostriate v, 3. internal
cerebral v, 4. basal v of Rosenthal, 5. v of Galen, 6. straight sinus, 7. inferior sagittal sinus
In the above diagram, the basal v of Rosenthal is labeled
A. 3
B. 4
c. 5
D. 6
E. 7
B. 4
- Septal v, 2. thalamostriate v, 3. internal
cerebral v, 4. basal v of Rosenthal, 5. v of Galen, 6. straight sinus, 7. inferior sagittal sinus
The yearly ri5k of rupture of cavernous malformations of the brain is
A. 0.5- 1%
B. 1-2%
c. 2-4%
D. 4-6%
E. 6-8%
**A. 0.5- 1% **
The annual risk of rupture of cavernous malformations is 0.5-1%, aneurysms 1-2%, and AVMs 2-4%.
Venous hypertension (Foix-Alajouanine syndrome) is found in which type( s) of spinal AVMs?
A. Type I
B. Type II
C. Type III
D. Type II and III
E. Type I and IV
Spinal AVMs types I and IV are high flow, low pressure, they present with venous hypertension;
while types II and III are high flow, high pressure,
they present with hemorrhage.
Neurofibrillary tangles and neuritic plaques are histolagic reatures of
A. Huntington’s chorea
B. Pick’s disease
C. Alzheimer’s disease
D. Wilson’s disease
E. Parkinson’s disease
C. Alzheimer’s disease
Histologic characteristics of neurodegenerative diseases. Alzheimer’s: neurofibrillary tangles and neuritic plaques; Huntington’s: caudate atrophy; Pick’s: Pick bodies; Wilson’s: Opalski cells; and Parkinson’s: Lewy bodies.
Which cranial nerves are involved in Collet-Sicard syndrome?
A. III and IV
B. V and VI
C. VII and VIII
D. IX, X, XI, and XII
E. None of the above combinations
D. IX, X, XI, and XII
Collet-Sicard syndrome is a unilateral lower
cranial nerves palsy (IX, X, XI, and XII) usually
caused by trauma or tumors.
Parkinson’s disease is primarily caused by degeneration of cells in
A. Subthalamic nucleus
B. Substantia nigra
C. Corpus striatum
D. Globus pallidus externus
E. Globus pallidus internus
B. Substantia nigra
Parkinson’s disease is caused by failure of dopaminergic output from the substantia nigra pars
compacta to the corpus striatum. Hemiballismus is caused by lesions of the subthalamic nucleus.
Huntington’s chorea, manganese, and methanol
toxicity affect the striatum. Athetosis has involvement of the globus pallidus externus, while carbon monoxide and manganese affect the globus pallidus internus.
Meralgia paresthetica causes pain and numbness in the
A. Medial thigh
B. Anterolateral thigh
C. Medial leg
D. Anterolateral leg
E. Sole of foot
B. Anterolateral thigh
Meralgia paresthetica is caused by entrapment or injury of the lateral femoral cutaneous n; it causes pain and numbness in the anterolateral thigh. The medial thigh is supplied by the ilioinguinal n, femoral n, and obturator n, medial leg by the saphenous n (a branch of the femoral n), anterolateral leg by the peroneal n, and the sole of the foot by the medial and lateral plantar nn (branches of the tibial).
Hypsarrhythmiaon EEG occurs in which syndrome?
A. LeMax-Gastaut syndrome
B. Absence seizures
C. Grand mat epilepsy
D. Night terrors
E. West syndrome
E. West syndrome
West syndrome is characterized by hypsarrhythmia on EEG: large bilateral slow waves with multifocal spikes; Lennox-Gastaut: spike-dome 1-2 Hz; absence: spike-dome 3 Hz; juvenile myodonic epilepsy: spike-dome 4-6 Hz; grand mat: repetitive spikes up to 100 pV. Night terrors occur in stages 3 and 4 of non-REM sleep
The main neurotransmitter of the climbing fibers is
A. Glutamate
B. GABA
C. Acetylcholine
D. 5-HT
E. Substance P
A. Glutamate
Climbing fibers consist of the olivocerebellar tract, which travels within the inferior cerebellar peduncle. Together with the granule cells, they synapse with Purkinje cell dendrites in the molecular cell layer, are excitatory, and secrete glutamate. Mossy fibers are also excitatory but end in the granular layer
The proatlantal a
A. Is located between the occiput and Cl
B. Is located between Cl and C2
C. Passes through the hypoglossal canal
D. Is found in the internal auditory canal
E. Connects ICA to ECA
A. Is located between the occiput and Cl
The proatlantal a is an anastomosis between the vertebral a and either the internal or external carotid a (ICA or ECA); it travels between the occiput and Cl. The hypoglossal a connects the ICA to the basilar a and travels through the hypoglossal canal. The acoustic (otic) a connects the ICA to the basilar a through the internal auditory canal.
Based on the ISUIA (International Study of Unruptured Intracranial Aneurysms), asymptomatic anterior circulation aneurysms should be treated if equal to or greater than
A. 2 mm
B. 3 mm
C. 5 mm
D. 7 mm
E. 10 mm
D. 7 mm
Based on the ISUIA study, the risk of rupture
of asymptomatic anterior circulation aneurysms,
excluding PCOM, <7 mm is very low.
The risk of stroke after a TIA over 2 years, in patients with >70% carotid artery stenosis, is
A. 6%
B. 11%
C. 26%
D. 50%
E. 60%
C. 26%
Based on NASCET (North American Symptomatic Carotid Endarterectomy Trial), carotid endarterectomy reduces the risk of stroke from 26% to 9% over 2 years in symptomatic patients with
70-99% stenosis, or 50-69% in high risk patients.
All of the following vessels contribute to the blood supply of the internal capsule, except
A. Anterior choroidal a
B. PCA
C. PCOM
D. Recurrent a of Heubner
E. Lateral lenticulostriate aa
B. PCA
The internal capsule is supplied by the anterior
choroidal, PCOM, Heubner, and lateral lenticulostriate aa. The PCA does not contribute to the blood supply of the internal capsule.
Normal cerebral blood flow is
A. <8 mL/100 g/min
B. 8-23 mL/100 g/min
C. 24-49 mL/100 g/min
D. 50 mL/100 g/min
E. 51-100 mL/100 g/min
D. 50 mL/100 g/min
The normal cerebral blood flow is 50 mL/100 g/ min, with higher flow in the gray matter than the white matter. In the ischemic penumbra. it is 8-23 mL/100 g/min. The normal Oxygen consumption is 3.5 mL/100 g/min.