Secretion II: Pancreatic Biliary

Question 1

Secretin function

Answer 1

Activate ductal cells to produce HCO3-

Question 2

CCK function

Answer 2

Activate acinar cells to produce enzymes

Question 3

Islets of Langerhan produce 2 hormones

Answer 3

Insulin and glucagon

Question 4

2 endocrine hormones

Answer 4

Glucagon and insulin

Question 5

Exocrine cells secrete

Answer 5

Enzymes

Question 6

2 Exocrine cells

Answer 6

Ductal and acinar

Question 7

What stimulates enzymes to go to acinar cells

Answer 7

Vagus nerve

Question 8

Stimulus of secretin

Answer 8

Acidity and fat

Question 9

Secretin action in stomach

Answer 9

Pepsinogen in chief cells

Question 10

Which cells produce pepsinogen

Answer 10

Chief cells

Question 11

Secretin receptor

Answer 11

SCTR

Question 12

CCK stimulus

Answer 12

Fats and proteins

Question 13

Actions of CCK in stomach

Answer 13

Increased HCl in parietal cells

Question 14

Which cells produce HCl

Answer 14

Parietal cells

Question 15

Which hormone produces decreased emptying

Answer 15

CCK

Question 16

Action of CCK in acinar cells

Answer 16

Produce more enzymes

Question 17

CCK receptor

Answer 17

CCKR2

Question 18

PS NS stimulus

Answer 18

Distension

Question 19

Function of PS NS in stomach

Answer 19

Increased emptying
Increased HCl in parietal cells
Increased pepsinogen in chief cells

Question 20

Action of PS NS in ductal cells

Answer 20

Increased HCO3 production

Question 21

PS NS receptor

Answer 21

M3 muscarinic

Question 22

HCO3 production dependent on

Answer 22

Carbonic anhydrase and CO2

Question 23

NBCe1-B transports…

Answer 23

HCO3- from blood into duct cell

Question 24

NHE1 transports..

Answer 24

H+ out of cell

Na+ into cell

Question 25

NBCe1-B and NHE1 located in

Answer 25

Basolateral membrane

Question 26

CFTR transports...

Answer 26

Cl - and HCO3- to lumen

Question 27

Secretin stimulates HCO3- production in ductal cells therefore... a what pH stimulates secretin

Answer 27

A low pH

Question 28

What 2 things stimulate HCO3- production

Answer 28

Secretin | PS NS

Question 29

Pancreatic amylase Trypsin and chymotrypsin Lipase Are enzymes produced by

Answer 29

Acinar cells

Question 30

Pancreatic amylase breaks down

Answer 30

Carbohydrates

Question 31

Trypsin and chymotrypsin break down

Answer 31

Proteins

Question 32

Lipase breaks down

Answer 32

Lipids

Question 33

Function of zymogen granules (2)

Answer 33

Produce and store pro-enzymes | Produce trypsin inhibitors

Question 34

Trypsin is active or inactive

Answer 34

Inactive

Question 35

What enzyme turns trypsin into trypsinogen

Answer 35

Enterokinase

Question 36

Vital thing about trypsin

Answer 36

To stay inactive in pancreas

Question 37

What happens if there is trypsinogen in the pancreas

Answer 37

It will digest the cell's protein

Question 38

Acinar cells produce ... to prevent trypsin activation

Answer 38

Trypsin inhibitors

Question 39

Pro-colipase and monitor peptide are also

Answer 39

Trypsin --> trypsinogen inhibitors

Question 40

pH is lowed in acinar cells because

Answer 40

H+ is secreted

Question 41

Ductal cells have a higher pH because

Answer 41

HCO3- is secreted

Question 42

Function of biliary secretion

Answer 42

Facilitate emulsion, solubilization and absorption of fats

Question 43

The bilis HAS NO

Answer 43

ENZYMES

Question 44

Another function of bilis helping ductal cells

Answer 44

Help in alkalization, increasing pH

Question 45

Function of biliary secretion in excretion

Answer 45

Excreting bilirrubin, cholesterol, excess drugs

Question 46

Bilis helps in synthesis of

Answer 46

Hepatocytes

Question 47

Hepatic parenchyma formed primarly of

Answer 47

Hepatocytes

Question 48

Hepatocytes main function

Answer 48

Produce bilis

Question 49

Bilis goes through

Answer 49

Biliary canaliculi into biliary ducts

Question 50

Canalicular component produced by

Answer 50

Hepatocytes

Question 51

Ductal component depends on

Answer 51

Secretion of biliary ducts

Question 52

Stimulation at ductular level

Answer 52

Secretin

Question 53

Secretin stimulates what in bilis and pancreas

Answer 53

Stimulates ductal cells in pancreas | Liver ducts

Question 54

Into what does the common bile duct flow into

Answer 54

The second part of the duodenum

Question 55

What other thing flows into the second part of the duodenum

Answer 55

The pancreatic duct

Question 56

The production of bile is

Answer 56

CONSTANT

Question 57

Function of gallbladder in relation to the bilis

Answer 57

It concentrates it.

Question 58

Colestistoquin function in gallblader

Answer 58

concentration of bile

Question 59

2 bile secretion phases

Answer 59

Cephalic-gastric phase | Intestinal phase

Question 60

Cephalic-gastric phase through

Answer 60

PS NS | Before food arrives some bile is released through relaxation of Oddi spincter

Question 61

Intestinal phase stimulus

Answer 61

CCK and secretin

Question 62

Synthesis of bile from

Answer 62

Cholesterol

Question 63

Emulsion of fat to small droplets through

Answer 63

Bile salts

Question 64

Function of bile salts

Answer 64

Emulsionate fat into small droplets to increase surface area

Question 65

What breaks down fat

Answer 65

Lipase

Question 66

Small aggregates of mixed lipids and bile acid

Answer 66

Micelles

Question 67

Micelles in bile salts function

Answer 67

Maintain lipids in solution | Transport them to enterocytes for their absorption