Secretion II: Pancreatic Biliary Flashcards
Secretin function
Activate ductal cells to produce HCO3-
CCK function
Activate acinar cells to produce enzymes
Islets of Langerhan produce 2 hormones
Insulin and glucagon
2 endocrine hormones
Glucagon and insulin
Exocrine cells secrete
Enzymes
2 Exocrine cells
Ductal and acinar
What stimulates enzymes to go to acinar cells
Vagus nerve
Stimulus of secretin
Acidity and fat
Secretin action in stomach
Pepsinogen in chief cells
Which cells produce pepsinogen
Chief cells
Secretin receptor
SCTR
CCK stimulus
Fats and proteins
Actions of CCK in stomach
Increased HCl in parietal cells
Which cells produce HCl
Parietal cells
Which hormone produces decreased emptying
CCK
Action of CCK in acinar cells
Produce more enzymes
CCK receptor
CCKR2
PS NS stimulus
Distension
Function of PS NS in stomach
Increased emptying
Increased HCl in parietal cells
Increased pepsinogen in chief cells
Action of PS NS in ductal cells
Increased HCO3 production
PS NS receptor
M3 muscarinic
HCO3 production dependent on
Carbonic anhydrase and CO2
NBCe1-B transports…
HCO3- from blood into duct cell
NHE1 transports..
H+ out of cell
Na+ into cell
NBCe1-B and NHE1 located in
Basolateral membrane
CFTR transports…
Cl - and HCO3- to lumen