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DIGESTIVO > Liver > Flashcards

Liver Flashcards

1
Q

Zone 1

A

Peripheral

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2
Q

Zone 2

A

Intermediate

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3
Q

Zone 3

A

Pericentral

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4
Q

Function of hepatic sinusoid w/ macromolecules

A

Macromolecules pass directly for hepatocyte absorption

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5
Q

Function of hepatic sinusoid in immunology

A

Endocyte immune complexes and present antigens to cells

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6
Q

What cells are located in Disse’s space

A

Ito cells

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7
Q

When are Ito cells in Disse’s space acitaved

A

In case of liver damage, fibrosis

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8
Q

What vitamin does Disse’s space hold

A

Vitamin A

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9
Q

Hepatic vascular system resistance

A

Low

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10
Q

Total L in hepatic vascular system

A

1.3L, 27% of CO

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11
Q

Main cause of portal hypertension

A

Stiffness in patients of cirrhosis

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12
Q

Consequence of portal hypertension in blood flow

A

Blood finds paths of less resistance

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13
Q

Which are the paths of less resistance

A

Collateral venous systems

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14
Q

Most important collateral venous systems

A

Esophageal varices

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15
Q

Cause of ascites

A

Due to increased pressure –> fluid accumulation so lymph present hydrostatic pressure
Fluid comes out of abdominal cavity

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16
Q

High pressure and low flow effect on spleen

A

Increase in size –> splenomegaly

17
Q

Consequence of splenomegaly

A

Spleen can now sequester platelets which can result in hypersplenism

18
Q

Liver regeneration through which cells

A

Mature hepatocytes

19
Q

The 3 phases of liver regeneration

A

Priming phase
Proliferating phase
Termination phase

20
Q

Priming phase constitutes

A

Inflammatory cytokines TNFa and IL-6

21
Q

Proliferation phase constitutes of

A

Growth factors, EGF and HGF

22
Q

Termination phase constitutes of

A

TGFb

23
Q

Regeneration with liver disease is

A

Impaired

24
Q

Function of Kupffer cells

A

Phagocytose bacteria so blood leaving the hepatic portal system is sterile

25
Q

Liver metabolic functions

A

Carbohydrate, lipid, protein metabolism

26
Q

Liver stores which vitamins

A

Vitamin A
Vitamin D
Vitamin B12

27
Q

Detoxification of drugs and toxins through which enzyme

A

Cytochrome P450

28
Q

Jaundice disease

A

Yelowish discoloration

29
Q

Heme metabolism function

A

Destroying fragile erythrocytes

30
Q

Heme –>

A

Biliverdin

31
Q

Heme –> biliverdin –>

A

Not conjugated bilirrubin

32
Q

Heme –> biliverdin –> not conjugated bilirrubin –>

A

Conjugated bilirrubin

33
Q

Heme –> biliverdin –> not conjugated bilirrubin –> conjugated bilirrubin –>

A

Urobilinogen

34
Q

Heme –> biliverdin –> not conjugated bilirrubin –> conjugated bilirrubin –> urobilinogen –>

A

Estercobilinogen or urobilin

35
Q

Stercobilinogen –>

A

Stercobilin

36
Q

Conjugated bilirubin –> urobilinogen. What is involved in this process

A

Microbiota

37
Q

In the case of jaundice, problem with bilirubin

A

There is an excess excretion of conjugated bilirubin

DIGESTIVO (5 decks)

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