Liver Flashcards
Zone 1
Peripheral
Zone 2
Intermediate
Zone 3
Pericentral
Function of hepatic sinusoid w/ macromolecules
Macromolecules pass directly for hepatocyte absorption
Function of hepatic sinusoid in immunology
Endocyte immune complexes and present antigens to cells
What cells are located in Disse’s space
Ito cells
When are Ito cells in Disse’s space acitaved
In case of liver damage, fibrosis
What vitamin does Disse’s space hold
Vitamin A
Hepatic vascular system resistance
Low
Total L in hepatic vascular system
1.3L, 27% of CO
Main cause of portal hypertension
Stiffness in patients of cirrhosis
Consequence of portal hypertension in blood flow
Blood finds paths of less resistance
Which are the paths of less resistance
Collateral venous systems
Most important collateral venous systems
Esophageal varices
Cause of ascites
Due to increased pressure –> fluid accumulation so lymph present hydrostatic pressure
Fluid comes out of abdominal cavity
High pressure and low flow effect on spleen
Increase in size –> splenomegaly
Consequence of splenomegaly
Spleen can now sequester platelets which can result in hypersplenism
Liver regeneration through which cells
Mature hepatocytes
The 3 phases of liver regeneration
Priming phase
Proliferating phase
Termination phase
Priming phase constitutes
Inflammatory cytokines TNFa and IL-6
Proliferation phase constitutes of
Growth factors, EGF and HGF
Termination phase constitutes of
TGFb
Regeneration with liver disease is
Impaired
Function of Kupffer cells
Phagocytose bacteria so blood leaving the hepatic portal system is sterile
