Secondary Immune deficiencies Flashcards
1
Q
what are the characteristics of infections in immunodef pts
A
severe
persistent
recurrent
unusual
2
Q
what malig are immunodef pts at risk of (and the cause)
A
EBV -> bercett’s lymphoma
HHV8 -> kaposi sarcoma
3
Q
name 4 types of drugs that cause secondary immune def (+ examples)
A
small mol - steroids, DMARDs, cytotoxic agents
JAK inhib (suppress cytokine transduction and action)
biologics - monoclonal Abs
cellular therapy - anti CD19, CAR-T therapy
4
Q
what do monoclonal Ab drugs end in
A
-mab
5
Q
what cancers will cause an antibody def
A
B cell lymphoproliferative cancers
6
Q
give 3 examples of B cell lymphoproliferative cancers
A
multiple myeloma
CLL
non-hodgekins lymphoma
7
Q
how would you manage a secondard immune def
A
Tx cause
avoid exposure to inf
immunisation
longer course of Ab for inf
