Innate Immunity Flashcards
stages of phagocytosis
pathogen taken up -> fuses with lysosome -> phagolysosome
how to phagocytes recognise path
PRRs - patter recog Rs (eg Toll-like Rs)
enz and mol involved in oxidative killing
NADPH oxidase (O2 -> O. )
superoxide dismutase (O. -> H2O2)
myeloperoxidase (H2O2 + Cl -> HOCL)
HOCL acts as oxidant and anti-microbial
what is used during non-ox killing
release of lysosomes and lactoferrin into phagolysosome
result of repeat phagocytosis
depletes neutrophil’s glycogen reserve -> cell death and enz release -> pus formation -> abscess
what do all natural killer cells express
express inhib R to ‘self’ HLA
express activating R to heparin sulphate proteoglycans
what makes up the complement and how is it activated
20 liver prod prot in circ in inactivated forms
activated by 3 pathways
where do the complement activation pathways converge
C3 (-> C5 -> C9)
what does activation of the complement form
membrane attack complex
what does membrane attack complex do
inc vasc perm, inc cell trafficking, opsonise patho, activate immune cells
where do dendritic cells reside
periph tissues
what do dendritic cells detect and via which R
detect inflam - cytokine/chemokine Rs
detect patho - PRRs
detect immune complexes
what are dendritic cells responsible for
change from innate to adaptive immunity
maturation of dendritic cells
immature cells - antigen recog and uptake
mature cells - entigen presentation to T cells
