HIV

Question 1

what receptors does HIV bind to

Answer 1

Co-R ( CCR5 or CXCR4)

Question 2

what viral antigens bind to CD4

Answer 2

gp120, gp41

Question 3

how does HIV interact with memory cells

Answer 3

integrates into mmry CD4 T cells to form a reservoir of latent inf

Question 4

what are the diagnostic investigations for HIV

Answer 4

ELISA
Western Blot
HIV-I genotype

Question 5

what baseline inv are take in a pt with HIV

Answer 5

bloods
sexual health screen
IGRA (for latent TB) 
CXR
ECG
Toxoplasma

Question 6

how do me monitor HIV pts

Answer 6

viral load
CD4+ count (flow cytometry)
CVS and Osteorporotic risk

Question 7

what vacinations are given to HIV pts

Answer 7

influenza A/B
SaARS-Cov2
pneumococcus

Question 8

what is the treatment for HIV

Answer 8

HAART - offer 2 Nucleoside RT inhib and one other drug, star asap

Question 9

Name 2 NRTIs

Answer 9

zidivudine

AZT

Question 10

what is the progression of untreated HIV

Answer 10

typical = 8-10y (85%)
rapid = <3 (10%)
long term non-progressors = >10-15y (5%)

Question 11

what natural abs are important in neutralising HIV

Answer 11

anti gp120

anti gp41