Adaptive immunity

Question 1

where are t cells made and where do they mature

Answer 1

made in BM

mature in thymus

Question 2

what do all T cells express

Answer 2

CD3 + T cell R

Question 3

what do CD4+ and CD8 + cells recog

Answer 3

4 = HLAII
8 = HLAI

Question 4

function of CD4+ cells

Answer 4

prod cytokines (TGFB)
stim dev of Treg cells

Question 5

function of CD8+ cells

Answer 5

cytotoxic
direct - perforin, granzymes = expression of Fas ligands
indirect cytokine secretion

Question 6

what do Treg cells express

Answer 6

CD25+

Foxp3+

Question 7

where do B cells arise and mature

Answer 7

arise and mature in BM

Question 8

what happens to B cells in BM

Answer 8

neg selection if recognise self antigens

Question 9

what happens to B cells after antigen presentation

Answer 9

-> plasma IgM cells
OR
-> germinal centre reaction - isotope switching and somatic hypermutation to prod IgG, IgE or IgA

Question 10

what stimulates germinal centre reaction

Answer 10

Tfh

Question 11

what CD does the germinal centre reaction require

Answer 11

CD40:CD40L

Question 12

what is the structure of IgG, IgA and IgM

Answer 12

G = monomer
A = dimer
M= pentamer

Question 13

which of the Igs can cross the placenta

Answer 13

IgG