Secondary Bleeding Disorders

Question 1

What is Glanzmann’s thrombasthenia?

Answer 1

No GPIIA/B on the platelets so fibrinogen can’t bind to stabilise platelets

This causes seconday bleeding with normal platelets and clotting factors. Increased TT

Question 2

What is Heamophilia?

Answer 2

X linked recessive

No FVIII - Haemophilia A

No Factor IX - Haemophilia B CHRISTMAS DISEASE

Symptoms - Increased APTT and purpura

Treatment - Desmopressin for haemophilia A as stabilises FVIII.

It can also be treated with transaxemic acid

Question 3

What happens with a Vitamin K deficiency?

Answer 3

Vitamin K is needed for factors 2,7,9,10 so you would get

Increased APTT, PT, TT

Eg, liver disease

Question 4

What happens with poor warfarin control?

Answer 4

Warfarin is a vitamin K antagonist so would cause prolonged PT (INR)

Question 5

What is disseminated intervascular coagulation?

Answer 5

Overstimulation of clotting factors so they are all used up causing simultaneous clotting and bleeding

Question 6

Summary of bleeding disorders

Answer 6

Question 7

What is the inheritance pattern of haemophilia?

Answer 7

X-linked recessive