Schizophrenia & psychosis Flashcards
What is Schizophrenia?
A group of brain disorders with characteristic distortion of thoughts, perception, behaviour & emotion
What are the positive symptoms in schizophrenia?
Delusions
Hallucinations
Thought disorder
What are the negative symptoms in Schizophrenia?
Apathy
Lack of volition
Social withdrawal
Cognitive impairment
In general do positive or negative symptoms respond better to treatment?
Positive
What are the 4 core criteia in schizophrenia?
Thought interference
Passivity phenomena
3rd person voices
Impossible persistent delusions
What are the other criteria for schizophrenia? (not the 4 core ones)
Formal thought disorder
Catatonic behaviour
Negative symptoms
Loss of interest/social withdrawal
What is the management of acute schizophernia?
IM olanzapine + risperidone
What is the frist line treatment for ongoing schizophrenia?
Risperidone
What is the management for treatment resistant schizophrenia?
Clozapine
What are the brain abnormalities in schizophrenia?
Reduction in temporal cortex & medial temporal lobe (esp. hippocampus)
Which gene alterations can predispose to schizophrenia?
Neuregulin
Dysbindin
DISC-1
What are the side effects of clozapine?
Agranulocytosis
Metabolic syndrome (more than other anti-pyschotics)
Salivation
Myocarditis
Why is clozapine not prescribed in the elderly?
Stroke & VTE risk
What does an emergency detention mean?
Can keep for up to 72 hours
Only emergency treatment
Not appealable
What does a short term detention mean?
Can keep for max 28 days
Can treat
Appealable