Schizophrenia & psychosis Flashcards

1
Q

What is Schizophrenia?

A

A group of brain disorders with characteristic distortion of thoughts, perception, behaviour & emotion

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2
Q

What are the positive symptoms in schizophrenia?

A

Delusions
Hallucinations
Thought disorder

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3
Q

What are the negative symptoms in Schizophrenia?

A

Apathy
Lack of volition
Social withdrawal
Cognitive impairment

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4
Q

In general do positive or negative symptoms respond better to treatment?

A

Positive

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5
Q

What are the 4 core criteia in schizophrenia?

A

Thought interference
Passivity phenomena
3rd person voices
Impossible persistent delusions

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6
Q

What are the other criteria for schizophrenia? (not the 4 core ones)

A

Formal thought disorder
Catatonic behaviour
Negative symptoms
Loss of interest/social withdrawal

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7
Q

What is the management of acute schizophernia?

A

IM olanzapine + risperidone

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8
Q

What is the frist line treatment for ongoing schizophrenia?

A

Risperidone

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9
Q

What is the management for treatment resistant schizophrenia?

A

Clozapine

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10
Q

What are the brain abnormalities in schizophrenia?

A

Reduction in temporal cortex & medial temporal lobe (esp. hippocampus)

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11
Q

Which gene alterations can predispose to schizophrenia?

A

Neuregulin
Dysbindin
DISC-1

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12
Q

What are the side effects of clozapine?

A

Agranulocytosis
Metabolic syndrome (more than other anti-pyschotics)
Salivation
Myocarditis

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13
Q

Why is clozapine not prescribed in the elderly?

A

Stroke & VTE risk

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14
Q

What does an emergency detention mean?

A

Can keep for up to 72 hours
Only emergency treatment
Not appealable

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15
Q

What does a short term detention mean?

A

Can keep for max 28 days
Can treat
Appealable

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16
Q

What does a compulsory treatment order mean?

A

Can keep for max 6 months
Can treat
Appealable

17
Q

What is the first line drug in the rapid tranquilisation protocol for a patient with no history of typical anti-psychotic use?

A

Lorazepam 1-2mg

18
Q

What is the first line treatment in the rapid tranquilisation protocol for a patient with a history of typical anti-psychotic use?

A

Lorazepam 1-2mg and/or haloperidol 5mg

19
Q

What is the next step in the rapid tranquilisation protocol after Lorazepam has been given?

A

Wait 30 mins

Repeat once if necessary