Psychiatry buzzwords Flashcards
Third person auditory hallucinations
Schizphrenia
Mesocortical dopamine hypoactivity
Negative and cognitive symptomsinschizophrenia
Subcortical dopamine hyperactivity causes…
Psychosis
What is thetuberofundibular pathway in the brain concerned with?
Prolacin release
What is the nigrostriatal tract concerned with?
Extra-pyramidal motor movements
What is the mesolimic system invloved in?
Motivation & reward
What is the mesolimbic pathway dysregulated in?
Schizophrenia
How does Da blockade compare to Da agonism in terms of clinical pressentation?
Da blockade - Depression
Da agonism - psychosis
Side effects of clozapine
Agranulocyosis
Cardiomyocitis
Weight gain
Which of the atypical anti-psychotics causes the most weight gain?
Olanzapine
When is clozapine indicated?
When have been tried on 2 other anti-psychotics and need to be a consultant to prescribe
How is clozapine monitored?
Once a week for 6 months
Then once every 2 weeks fro 6 months then every 4 weeks thereafter and a month after discontinuation
What are the functions of the limbic system?
M2 - Memory, Motivation
O- Olfaction
V - Visceral afferents
E - Emotion
What are the brain changes in schizophrenia?
Reduced frontal lobe volume (and grey matter)
Enlarged lateral ventricles
Reduced grey matter in the temporal cortex
What is pressure of thought
Varied ideas in abundance (characteristic of mania but also seen in schizophrenia)