Schizophrenia: Paper 3 Flashcards
What is Schizophrenia?
What can it lead to?
A group of disorders whereby people interpret reality abnormally.
It can result in a combination of hallucinations, delusions and extremely disordered thinking and behaviour that can impair daily functioning.
What are positive symptoms?
Positive symptoms enhance the typical experience of schizophrenic sufferers and occur in addition to their normal experiences such as hallucinations and delusions.
What are negative symptoms?
Negative symptoms take away from the typical experience of schizophrenic sufferers, and so represents a ‘loss’ of experience e.g. speech poverty and avolition.
What are auditory hallucinations and what type of symptom it?
It is a positive symptom in which the individual may hear voices in the person’s mind either talking each other or to the person.
What are delusions, can you give all the types of delusions?
Is it a positive or negative symptom?
Positive symptom!
Delusions are false beliefs which remain despite confirmation or otherwise by logic.
This means that people with delusions cannot distinguish between their private thoughts and external reality such as:
- Delusions of Grandeur, which refers to a false impression of one’s own importance.
- Delusions of Persecution, an irrational belief that others are trying to plot against or kill the individual.
- Delusions of Control, the false belief that another person, group of people or external forces like aliens are trying to take control of one’s thoughts, feelings, impulses or behaviours.
What is affective flattening?
What type of symptom is it?
It is a negative symptom!
A reduction in the range and intensity of emotional expression such as having a lack of body language.
For example, fewer body and facial movements.
What is anhedonia?
Is it a positive or negative symptom?
If you think you’re cold can you tell me the difference between two different types of anhedonia, and why one is perhaps more reliable than the other?
It is a negative symptom!
Anhedonia refers to a loss of pleasure or interest in all or almost all activities or a lack of reactivity to normally pleasurable stimuli.
Physical anhedonia refers to the inability to experience physical pleasures such as from food whereas social anhedonia refers to the inability to experience pleasure from interpersonal situations such as interacting with other people.
Some may say that physical anhedonia is considered a more reliable symptom of schizophrenia because it does not overlap with other disorders like depression unlike social anhedonia.
What is avolition?
Is it a positive or negative symptom?
It is a negative symptoms!
Avolition refers to a reduction of interests and desires as well as an inability to initiate and persist in goal-directed behaviour such as not taking showers.
What is speech poverty?
Is it a positive or negative symptom?
It is a negative symptom!
Speech poverty is a lessening of speech fluency and productivity.
It is thought to reflect slowing or blocked thoughts. For example, fewer words may be produced in a given time on a task of verbal fluency.
What are the main differences between classification of schizophrenia in the DSM-5 and the ICD-10?
For the DSM 5 - there most be at least one positive symptom. It is used in America.
Whereas…
ICD-10 - Two or more negative symptoms are sufficient for diagnosis. It is used worldwide.
Discuss issues of reliability and validity associated with the classification and/or diagnosis of schizophrenia. (16 marks)
What is Diagnostic Reliability?
A01: Classification and/or diagnosis of schizophrenia
Diagnostic Reliability means that a diagnosis of schizophrenia must be repeatable.
This means that different clinicians using the same system (such as DSM-5) should arrive at the same diagnosis:
- for the two clinicians studying the same schizophrenic patient (inter-rater reliability).
- for testing schizophrenic patients at two different points in time (test-retest reliability).
What is cultural bias in schizophrenic and how can this limit the reliability and validity of diagnosing schizophrenia?
A01: Classification and/or diagnosis of schizophrenia
Cultural bias in schizophrenia refers to how the cultural assumptions of psychiatrists have an impact on their diagnosis of people from different cultural backgrounds or origins with Schizophrenia.
If diagnosis is not consistent among different cultures, the reliability of diagnosis of schizophrenia can be questioned.
What is validity and how does this relate to the diagnosis in schizophrenia?
A01: Classification and/or diagnosis of schizophrenia
Validity refers to the extent that the diagnosis of schizophrenia represents something that is real and distinct from other disorders and the extent that a classification system such as DSM 5 measures what it sets out to measure.
How can gender bias relate to the diagnosis of schizophrenia?
A01: Classification and/or diagnosis of schizophrenia
Gender bias in the diagnosis of schizophrenia refers to the accuracy of the diagnosis being dependent on the individual’s gender.
This is because the accuracy of diagnostic judgements can vary for a number of reasons such as clinicians basing their judgements on stereotypical beliefs held about a gender.
How do different manuals diagnose schizophrenia differently?
A01: Classification and/or diagnosis of schizophrenia
There are different diagnosing manuals that look for different characteristics meaning that diagnosis may depend on the manual used.
What is co-morbidity, and how can it affect diagnosis of schizophrenia?
A01: Classification and/or diagnosis of schizophrenia
Co-morbidity describes people who suffer from two or more mental disorders.
Psychiatric co-morbidities are common among patients with schizophrenia.
This is a problem which could decrease the validity when diagnosing schizophrenia because co morbidity makes it more difficult to confidently diagnose schizophrenia.
Cultural bias: Tendency to over diagnose members of other cultures.
Do you know any research support for this statement?
A03: Classification and/or diagnosis of schizophrenia
Research shows that there is a tendency to over diagnose members of other cultures.
For example, Cochrane found that the incidence of schizophrenia in the West Indies is similar to the UK at 1% but found that people of Afro-Caribbean origin are seven times more likely to be diagnosed with schizophrenia when living in the UK
Why is this a problem for diagnosing schizophrenia?
(to achieve a second mark)
A03: Classification and/or diagnosis of schizophrenia
This is a problem because the reason for this may be due to the original construction of the diagnosis system in the West now being applied to culturally different people means that the validity of diagnosing schizophrenia can be questioned because it does not account for cultural differences, thus leading to an inaccurate diagnosis of schizophrenia.
High-inter-rater reliability…
A03: Classification and/or diagnosis of schizophrenia
One strength of the diagnosis of schizophrenia is that using the DSM classification appears to have high inter-rater reliability over time.
This is a strength because research support from Beck found 54% concordance between experienced practitioners diagnoses when assessing 153 patients using the DSM classification system, while Soderberg reported an 81% concordance rate of schizophrenia.
How does this support the reliability of diagnosing schizophrenia?
A03: Classification and/or diagnosis of schizophrenia
This supports the notion that schizophrenia can be diagnosed consistently over time and thus diagnosis of schizophrenia has become more reliable.
Gender bias in diagnosing schizophrenia
A03: Classification and/or diagnosis of schizophrenia
This is a limitation because men have consistently been diagnosed with schizophrenia more than woman.
Research support to explain this comes from Cotton et al who found female patients with negative symptoms of schizophrenia can typically function better than men- and therefore escape diagnosis of schizophrenia.
Moreover, Loring and Powell found that some behaviours which was regarded as psychotic in males were not regarded as psychotic in females.
How does this limit the reliability of diagnosing schizophrenia?
A03: Classification and/or diagnosis of schizophrenia
Therefore, the reliability of the diagnosis of schizophrenia is low because men and women with the same symptoms may get different diagnoses, meaning that diagnosis is not consistent.
How can different manuals used show that there is lack of validity in diagnosing schizophrenia?
A03: Classification and/or diagnosis of schizophrenia
If there was consistency, then they would’ve diagnosed the same number of people using both diagnostic tools, and yet, they varied.
This shows a lack of validity as different diagnostic tools will diagnose people differently, so one patient may be diagnosed as schizophrenic under the DSM, but not the ICD.
This means that some people will be misdiagnosed, or not diagnosed at all, and therefore have the potential to miss out of the appropriate treatment
Contradictory research support for inter-rater reliability
A03: Classification and/or diagnosis of schizophrenia
Cheniaux et al (2009) found that inter-rater reliability amongst two psychiatrists was low.
One diagnosed 26 out of 100 patients with schizophrenia using the DSM, and 44 out of 100 using the ICD. The other diagnosed 13 using the DSM and 24 using the ICD.
How can co-morbidity undermine the usefulness of diagnosing schizophrenia?
A03: Classification and/or diagnosis of schizophrenia
Research support from Buckley found that 50% of the patients diagnosed with schizophrenia also were diagnosed with depression.
This is a limitation because it undermines the usefulness of diagnosis and classification systems of schizophrenia.
This is because if half as many patients with schizophrenia also have severe depression it suggests that schizophrenia could be one single condition, affecting the validity of diagnosing schizophrenia.
Research support from Loring and Powell for existence of gender and cultural bias
A03: Classification and/or diagnosis of schizophrenia
Loring and Powell sent 290 psychiatrists two identical case studies, the psychiatrists changed the gender and race of the case studies to different genders and races and a control situation in which no gender or race is disclosed.
The researchers found an over diagnosis of black case studies and under-diagnosis of female case studies.
When the race and gender of the psychiatrist was the same, an accurate diagnosis was achieved.
This suggests the existence of both gender and cultural bias in psychiatrists diagnosis of schizophrenia.
Outline and Evaluate the Biological Explanations of Schizophrenia. (16 marks)
How are twin studies used to explain why people inherit schizophrenia?
A01: Biological Explanations of Schizophrenia
One biological explanation is that schizophrenia is inherited/passed on through twin studies.
By comparing the concordance rates between MZ and DZ twins we can determine the likelihood of genetic inheritance of schizophrenia.
If MZ twins have a higher concordance rate than DZ twins, we can determine that schizophrenia was inherited.
What does the Dopamine Hypothesis theory propose about people with schizophrenia?
A01: Biological Explanations of Schizophrenia
The Dopamine Hypothesis theory suggests that symptoms of schizophrenia are associated with an imbalance of the dopamine neurotransmitter across the brain.
What is the difference betweem ‘hyperdopaminergia’ and ‘hypodopamingeria’?
A01: Biological Explanations of Schizophrenia
Excessive amounts of dopamine (this is called hyperdopaminergia)
in speech areas such as the Broca’s area could lead to positive symptoms such as auditory hallucinations.
WHEREAS…
Lower levels of dopamine (this is called hypodopaminergia) in areas like the frontal cortex lead to negative symptoms such as avolition or speech poverty.
Drugs been developed to treat schizophrenic symptoms…
Tell me how amphetamines treat schizophrenic symptoms…
A01: Biological Explanations of Schizophrenia
Amphetamines increases dopaminergic activity by stimulating nerve cells containing dopamine, flooding the synapse.
It has been found that giving normal individuals large doses of dopamine releasing drugs such as amphetamines leads to schizophrenic symptoms such as hallucinations and delusions.
Thus, amphetamines have been used to treat schizophrenics suffering from negative symptoms.
Drugs been developed to treat schizophrenic symptoms…
Tell me how antipsychotics treat schizophrenic symptoms…
A01: Biological Explanations of Schizophrenia
Antipsychotics decreases dopaminergic activity.
By reducing the activity in the neural pathways of the brain that use dopamine as the neurotransmitter, this leads to the elimination of these positive schizophrenic symptoms such as hallucinations.
Socially sensitive, perhaps other approaches may be more suitable in explaining schizophrenia…
(2 marks)
A03: Biological Explanations of Schizophrenia
A biological approach to explaining schizophrenia, such as a genetic basis assumes that schizophrenia is inevitable, or biologically determined.
Potentially making sufferers feel disempowered when diagnosed.
Other more psychological approaches such as the cognitive approach has a soft determinist perspective suggesting that mental processes can be altered or managed via free will to control the disorer.
How has the development of psychotic drugs helped the economy?
A03: Biological Explanations of Schizophrenia
This has positive implications for the economy because it means patients can return to their homes, saving the NHS money on hospitalisations for schizophrenia, reducing the burden on the NHS (with already very long waiting times).
It also allows patients to go back to work and contribute to the economy.
Biological reductionism is highly scientific and has practical applications…
A03: Biological Explanations of Schizophrenia
Explaining schizophrenia at the basic cellular and chemical level has the advantage of the scientific principle of parsimony.
This has allowed for the development of antipsychotic drugs, which are the primary course of treatment for this condition.
These drugs are indispensable treatment for schizophrenia and the fact that they have dramatically improved the lives of schizophrenic sufferers and their families is a real strength of the dopamine hypothesis.
Research support for implications of dopamine in causing schizophrenia through effectiveness of drugs…
A03: Biological Explanations of Schizophrenia
Barlow & Durand (1995) report that chlorpromazine is effective in reducing schizophrenic symptoms in about 60% of cases. The drug blocks dopaminergic activity receptors and reduces its levels.
Clearly shows that dopaminergic activity is implicated in schizophrenia because the study demonstrates that using a dopaminergic activity blocking drug like chlorpromazine is effective in treating schizophrenia in many cases.
Genetic mutations support the genetic explanation of schizophrenia
A03: Biological Explanations of Schizophrenia
This is because it is possible for people to develop schizophrenia even in the absence of a family history of the disorder.
This could be through mutation in the paternal DNA in the sperm because of mutagenic agents.
Brown et al found a relationship between paternal age (which is linked with an increased risk of mutation) and the risk of developing schizophrenia. He found that in men under 25 the risk was 0.7% and men over 50 was 2%.
Therefore, the older the father, the higher the risk that the child develops schizophrenia, supporting the theory of the genetic explanation
Other factors such as those in the environment may have played a role in schizophrenia…
A03: Biological Explanations of Schizophrenia
The fact that the concordance rates are not 100% means that schizophrenia cannot be solely explained by genes and therefore the environment could have also played a role in the development of schizophrenia.
This means that the biological explanation of schizophrenia does not give a full explanation of the schizophrenia disorder.
Taking an interactionist approach may be necessary…
A03: Biological Explanations of Schizophrenia
Alternatively, the diathesis stress model may be a more suitable explanation to explain schizophrenia as it combines both biological and psychological factors in the development of schizophrenia, providing a more holistic approach to explaining schizophrenia.
This is because this explanation considers not only the development of schizophrenia determined by a biological predisposition but also the environmental stressors within an individual’s lives that trigger this vulnerability, causing schizophrenia.
Gottesman and Shield: Research support from twin studies
A03: Biological Explanations of Schizophrenia
Gottesman reviewed cases of schizophrenia and found a concordance rate of 48% for MZ twins and 17% for DZ twins.
This suggests that schizophrenia has a genetic aspect because MZ twins had a significantly higher concordance rate than DZ twins.
Research support from effectiveness of antipsychotic drugs.
A03: Biological Explanations of Schizophrenia
Leucht et al carried out a meta-analysis of 212 studies which analysed the effectiveness of different antipsychotic drugs compared with a placebo.
They found all drugs tested were significantly more effective than the placebo in the treatment of positive and negative symptoms.
The effectiveness suggests that dopamine does play an important role in the development of schizophrenia.
Research support from Cognitive Neuroscience
A03: Biological Explanations of Schizophrenia
Kesler et al (2000) used MRI and PET scans to compare schizophrenic and non-schizophrenic participants. They found differences in dopamine levels suggesting that dopamine is an important factor in the onset of schizophrenia.
This study supports the dopamine strand as the finding shows that dopamine levels are different in non-schizophrenics and schizophrenics.
Outline and discuss the neural correlates explanation of schizophrenia. (8 marks)
What are neural correlates?
A01: Neural correlates explanation of schizophrenia
Neural correlates are patterns of structure or activity in the brain that occur in conjunction with schizophrenia
What are ventricles and how can this relate to schizophrenia?
A01: Neural correlates explanation of schizophrenia
Ventricles are fluid filled cavities (i.e. holes) in the brain that supply nutrients and remove waste.
It has been found that the ventricles of a person with schizophrenia are on average about 15% bigger than normal (Torrey, 2002).
Researchers have also found that many people with schizophrenia, particularly those displaying negative symptoms have enlarged ventricles.
What is the difference betweem ‘hyperdopaminergia’ and ‘hypodopamingeria’?
How can they produce schizophrenic symptoms?
Tested again, to see if you remember previous flashcard :)
A01: Neural correlates explanation of schizophrenia
Excessive amounts of dopamine (this is called hyperdopaminergia)
in speech areas such as the Broca’s area could lead to positive symptoms such as auditory hallucinations.
WHEREAS…
Lower levels of dopamine (this is called hypodopaminergia) in areas like the frontal cortex lead to negative symptoms such as avolition or speech poverty.
Current understanding of the role of dopamine in schizophrenia is that both hyperdopaminergia and hypodopaminergia may be at work in different brain areas to produce schizophrenia
Biological determinism & social sensitivity.
A03: Neural correlates explanation of schizophrenia
A neural correlates explanation of schizophrenia is an example of biological determinism as it assumes that specific brain structures and/or dopaminergic activity in the brain play a key role in the onset of schizophrenia
This suggests that the dopamine hypothesis does not account for freewill and could potentially make sufferers feel disempowered when diagnosed as they feel that they cannot do anything about their illness.
Most research into neural correlates is correlational…
A03: Neural correlates explanation of schizophrenia
The research evidence for neural correlates takes (as the name suggests) a correlational approach to mapping brain regions to schizophrenia which means that it lacks a cause-effect explanation
There is no acknowledgement of the role of the environment to a neural correlates-based explanation of schizophrenia which means that it lacks external validity
Neural correlates explanation is highly scientific…
A03: Neural correlates explanation of schizophrenia
One strength is that the biological explanation of schizophrenia using neural corelates uses highly scientific procedures and standardised procedures.
These machines take accurate readings of brain regions such as the frontal and pre-frontal cortex, the basil ganglia, the hippocampus and the amygdale.
This suggests that if this research was tested and re-tested the same results would be achieved, high test-retest reliability
Research support for enlarged ventricles
A03: Neural correlates explanation of schizophrenia
Supporting evidence for the brain structure explanation comes from further empirical support from Suddath et al. (1990).
He used MRI (magnetic resonance imaging) to obtain pictures of the brain structure of MZ twins in which one twin was schizophrenic.
The schizophrenic twin generally had more enlarged ventricles and a reduced anterior hypothalamus. The differences were so large the schizophrenic twins could be easily identified from the brain images in 12 out of 15 pairs.
This suggests that there is wider academic credibility for enlarged ventricles determining the likelihood of schizophrenia developing.
Discuss psychological explanations of schizophrenia (16 marks)
What do explanations based on family dysfunction explanations claim?
A01: Psychological explanations of schizophrenia
Explanations based on family dysfunction claim that schizophrenia is caused by abnormal patterns of communication within the family.
It is argued that poor relationships and communication in families increase the risk of developing schizophrenia.
What are mixed messages in relation to schizophrenia?
A01: Psychological explanations of schizophrenia
Parent gives contradictory messages by verbally communicating a message but non-verbally rejecting another message.
When the child ‘disobeys’, the parent punishes the child by withdrawing their love.
As a result of these mixed messages from parents, the child fears voicing objections about their unfair treatment and becomes confused and doubtful.
Can you provide an example of ‘Mixed Messages’ and what psychologists have suggested about how it leads to the development of schizophrenia?
A01: Psychological explanations of schizophrenia
An example of mixed messages would be telling a child that they need to be more independent and then the parent becomes overprotective and critical of their child’s attempts to be independent.
Bateson suggested that this upbringing affects the child’s internal reality resulting in disorganised thinking and paranoia.
What is expressed emotion in relation to schizophrenia?
A01: Psychological explanations of schizophrenia
Expressed emotion refers to communication patterns which involve high levels of negative emotion expressed to the schizophrenic patient from their carers, which contribute to schizophrenia.
Can you provide an example of expressed emotion, and research to support expressed emotion impacting schizophrenic behaviour?
A01: Psychological explanations of schizophrenia
Examples of behaviours shown by families with high expressed emotions can be:
- Exaggerated involvement. This is when families indicate that the sufferer is a burden through self-sacrifice such as by reminding the sufferer what an inconvenience they are all the time.
- Over-involvement in a patients life. This lack of freedom could lead to the development of positive symptoms such as hallucinations and is a major cause of relapse.
Research support for Hooley found that 705 of schizophrenic sufferers from families with expressed emotion relapse while only 30% with low expressed emotions relapse when the patient returns after being hospitalised.
Practical applications
A03: Psychological explanations of schizophrenia
One strength of the research into expressed emotion is that it has practical applications.
Family therapy has been demonstrated to reduce expressed emotion in families and to be an effective intervention for reducing relapse rates
The fact that family therapy for psychosis is effective shows that psychological factors are involved in schizophrenia thus supporting the argument that family dysfunction causes schizophrenia.
Ignores individual differences as expressed emotions does not always lead to schizophrenia.
A03: Psychological explanations of schizophrenia
However one limitation is that not all patients who live in high expressed emotion families relapse, and not all patients who live in low expressed emotion homes avoid relapse.
Research has shown individual differences in stress response to high expressed emotional behaviour.
For example, vulnerability may be physiological as one quarter of patient studies showed no physiological responses to stressful comments made by their relatives.
This is a limitation because it shows that not all patients are equally vulnerable to high levels of expressed emotion within the family.