Schizophrenia

Question 1

Typical Antipsychotics - FGA: 3 types

Answer 1

Phenothiazines: Chlorpromazine, Thioridazine, Fluphenazine
Butyrophenones: Haloperidol
Thioxanthenes: Zuclopentixol, Flupentixol (depot)
Substituted benzamides: Sulpride

Question 2

What is the differences between FGA and SGA?

Answer 2

FGA: First Generation Antipsychotics
SGA: Second Generation Antipsychotics

Question 3

Adverse effects: FGAs

Answer 3

Block a-adrenorecpetor = sexual dysfunction
Block H1 = sedation, weight gain
Block muscarinic = dry mouth, blurred vision, constipation

Question 4

Mechanism of action: FGAs

Answer 4

Block DA at D2 recpetors in mesolimbic pathway
If blocked in basal ganglia = EPS
If blocked in hypothalamus-pituitary gland = endocrine effects

Question 5

Atypical Antipsychotics - SGAs

Answer 5

Clozapine
Olanzapine
Quetiapine
Risperidone
Aripiprazole
Paliperidone
Amisulpride

Question 6

Adverse Effects: SGAs

Answer 6

Less EPS, weight gain, induction of diabetes (‘ines), sexual dysfunction, QT prolongation, hypotension, tachycardia

Question 7

Mechanism of action: Clozapine, Olanzapine, Quetiapine, Risperidone

Answer 7

Affinity for 5-HT2A and D2 receptors

Question 8

Mechanism of action: Aripiprazole, Paliperidone

Answer 8

Partial DA antagonists

Question 9

Mechanism of action: Amisulpride

Answer 9

Block D2 and D3 subtypes

Question 10

Interactions for SGAs

Answer 10

Beta blockers, alcohol, AEDs