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MPH322 - CNS Drugs > ADHD > Flashcards

ADHD Flashcards

1
Q

What does ADHD stand for?

A

Attention deficit hyperactivity disorder

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2
Q

What is first line of treatment?

A

Stimulants -

  1. Methylphenidate
  2. Lisdexamfetamine
  3. Dexamfetamine
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3
Q

Adverse effects of stimulants

A

Methylphenidate - Insomnia, GI effects, CV effects
Avoid abrupt withdrawal

Lisdexamfetamine and Dexamfetamine - Drowsy (driving)

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4
Q

Mechanism of action of Methylphenidate

A

Increases intrasynaptic dopamine + noradrenaline in frontal cortex

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5
Q

Mechanism of Lisdexamfetamine and dexamfetamine

A

Increases intrasynaptic dopamine + noradrenaline in frontal cortex

Also – block vesicular MA transporter to increase levels

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6
Q

What interactions should we be aware of with Methylphenidate?

A

Monitor pulse, BP, weight, height

Anticoagulants, MAOIs, AEDs, antidepressants

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7
Q

What interactions should we be aware of with Lisdexamfetamine and dexamfetamine

A

MAOIs, antidepressants, moclobemide, rasagiline

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8
Q

Second line ADHD treatment

A

Atomoxetine

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9
Q

When should Atomoxetine be taken?

A

Take second dose at teatime so does not disturb sleep

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10
Q

Atomoxetine adverse effects

A

GI effects, increased hr + bp, prolongs QT interval

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11
Q

Mechanism of action for atomoxetine

A

SNRI, no CNS stimulant activity

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12
Q

What interactions should we be aware of with atomoxetine?

A

MAOIs, drugs that prolong QT interval, terbinafine

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13
Q

Name four drugs that could be used as a third line option

A

Bupropion
Modafinil
Noradrenergic antidepressants
Clonidine

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14
Q

Name Adverse effects of Buproprion, Modafinil and Noradrenergic antidepressants

A

GI, dizzy, dry mouth, fever, headaches, drowsiness

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15
Q

Name Adverse effects of Clonidine

A

Nausea, vomiting, antimuscarinic, headache

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16
Q

Mode of action for Buproprion, Modafinil and noradrenergic antidepressants

A

Antagonises nACh receptors

Enhances dopamine release

17
Q

Mode of action from Clonidine

A

Stimulates alpha-adrenoceptors

18
Q

What interactions should we be aware with Buproprion, modafinil and noradrenergic antidepressants

A

Antidepressants, some opioids, AEDs

MPH322 - CNS Drugs (7 decks)

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