Schizophrenia Flashcards

1
Q

In the ICD-10 criteria for schizophrenia, 1st rank symptoms

A
  1. thought disorders
  2. delusions of control, passivity
  3. auditory hallucinations
  4. other inappropriate/ impossible persistent delusions
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2
Q

In the ICD-10 criteria for schizophrenia, other symptoms after 1st rank

A
  1. Persistent hallucinations + delusions
  2. Breaks in train of thought (causing incoherence)
  3. Catatonic behaviour (excitement, stupor)
  4. Negative symptoms (eg marked apathy)
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3
Q

6 types of thought disorders

A
  1. thought block
  2. thought withdrawal
  3. thought insertion
  4. thought broadcasting
  5. thought echo/ audible thought
  6. breaks in train of thought
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4
Q

3 categories of symptoms in schizophrenia

A
  1. Reality distortion: delusions and hallucinations
  2. Disorganisation: thought disorder
  3. Psychomotor poverty: similar to negative symptoms
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5
Q

Negative symptoms in schizophrenia

A
•	Blunted emotions, anhedonia
•	Poverty of thought: Not thinking much about anything
•	Social withdrawal
•	Apathy, loss of energy
•	Impaired attention
•
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6
Q

Define delusions

A

Fixed false beliefs, cannot be corrected by logic.

Not consistent with culture and education of patient.

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7
Q

Difference between hallucinations and illusions

A

Hallucination = false perception without external stimulus

Illusion = misperception of real external stimulus

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8
Q

Difference between real vs pseudo auditory hallucinations

A

Real: hearing 3rd person voice talking about you

Pseudo: hearing your own voice in your head

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9
Q

In what type of disorders are pseudo-hallucinations common

A

Personality disorders

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10
Q

Delusions that exist in psychosis vs depression

A

PSYCHOSIS DELUSIONS

  • grandoise
  • delusional perception
  • delusional reference
  • passivity

DEPRESSION DELUSIONS

  • nihilistic
  • guilt
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11
Q

4 main subtypes of schizophrenia

A
  1. Paranoid
  2. Disorganised/ hebephrenic
  3. Catatonic
  4. Residual
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12
Q

What are nihilistic delusions

A

Believing that parts of body are rotting or dead

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13
Q

What are Fregoli delusions

A

Thinking that different people are a single person in disguise

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14
Q

What motor disorders may occur as a side effect of antipsychotics

A
  • Dystonia
  • Parkinsonism
  • Akathisia
  • Tardive dyskinesia
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15
Q

Difference between delusional disorder and schizophrenia

A

Schizophrenia features formal thought disorder (alongside delusions, hallucinations)
Delusional disorder only has delusions.

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16
Q

When is the peak onset of schizophrenia

A

Early adulthood

17
Q

Risk factors for schizophrenia

A
  • genetics
  • preterm birth, hypoxic birth
  • drug abuse eg amphetamines
  • significant life events
18
Q

Serious medical side effects of antipsychotics

A
  • T2DM

- Cardiovascular disease

19
Q

What is the dopamine theory of schizophrenia

A

Schizo is due to excess of dopamine (either too much dopamine or too many receptors) in basal ganglia (striatum)

20
Q

MoA of antipsychotic drugs

A

D2 receptor antagonists

21
Q

How long do antipsychotics take to work

A

2-3 weeks

22
Q

Side effects of antipsychotics

A
  1. Extrapyramidal (Parkinsonism, tardive dyskinesia, akanthesia)
  2. Anticholinergic (dry eyes, urinary retention)
  3. Anti adrenergic (tachycardia, postural hypotension, sexual dysfunction)
  4. Antihistamine (sedation, weight gain)
  5. QT prolongation
  6. Neuroleptic malignant syndrome
23
Q

Symptoms of neuroleptic malignant syndrome

What causes it

A

Due to blockage of dopamine receptors

Symptoms

  • Muscle rigidity
  • High fever
  • Fluctuating consciousness
24
Q

Complications of neuroleptic malignant syndrome

A

Rhabdomyolysis
Hyperkalemia, kidney failure
Seizures

25
Q

Risk factors for poor prognosis in schizophrenia

  • family history
  • onset
  • education
  • premorbid personality
  • age
A
  • strong family history
  • gradual onset, no obvious precipitation
  • low education
  • premorbid history of social withdrawal
  • younger age of onset