Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Psychiatry > Schizophrenia > Flashcards

Schizophrenia Flashcards

1
Q

Which dopamine pathway is responsible for the +ve Sx?

A

Mesolimbic pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Which dopamine pathway is responsible for the -ve Sx?

A

Mesocortical pathway

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the +ve Sx of schizophrenia?

A

Hallucinations and delusions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the -ve Sx of schizophrenia?

A

Poverty of speech, flat affect, poor motivation, social withdrawal and lack of concern for social convention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What are the 1st rank (cardinal) Sx of schizophrenia?

A
  1. Third-person auditory hallucinations
  2. Thought echo
  3. Delusional perception – believe actual things are ‘giving them a message’
  4. Thought insertion/withdrawal/broadcast
  5. Delusions of passivity
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What are the 2nd rank Sx of schizophrenia?

A
  1. Second-person auditory hallucinations
  2. Catatonic behaviour
  3. Negative symptoms
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What are the three neurological Sx that have been seen in schizophrenia?

A
  1. Hyperactivity of dopaminergic, serotonergic and noradrenergic systems
  2. Enlargement of the lateral and third ventricles
  3. Abnormalities of the frontal lobes
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the advantages of typical antipsychotics?

A
  1. Cheap
  2. Have been used for a long time - lots of experience with them
  3. Can be injected - long-acting depot can be used in patients with poor compliance
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the types of S/Es that can occur with typical?

A

Dopamine
Histamine
Anticholinergic
Alpha-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the Alpha-1 S/Es of typicals?

A
  1. Impotence

2. Postural hypotension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the anticholinergic S/Es of typicals?

A
  1. Constipation
  2. Blurred vision
  3. Dry mouth
  4. Confusion
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the histamine S/Es of typicals?

A
  1. Sedation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What are the dopamine S/Es of typicals?

A
  1. Hyperprolactinaemia - galactorrhoea, impotence
  2. Acute dystonia - e.g. oculo-gyric crisis
  3. Parkinsonism
  4. Akathasia - restless legs
  5. Tardive dyskinesia - e.g. lip-smacking
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

How may dopamine S/Es (EPSEs) be managed?

A

Procyclidine (except akathasia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What may procyclidine also be used for?

A

Acute dystonic reaction than can occur with haloperidol OD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

How may akathasia be managed?

A

Lorazepam (or BZD, or beta-bloker)

17
Q

What are the ‘other’ S/Es of typical?

A
  1. Weight gain
  2. Arrhythmia
  3. Decreased seizure threshold
  4. Neuroleptic malignant syndrome
18
Q

What is the mnemonic for neuroleptic malignant syndrome?

A

FEVER

F - fever
E - elevated enzymes (CK) 
V - vitals unstable
E - encephalopathy
R - renal failure (+DCIS)/rigidity
19
Q

What are some examples of typicals?

A

Haloperidol

20
Q

What are some examples of atypicals?

A

Olanzapine, amisulpride, risperidone, aripiprazole

21
Q

What are the advantages of atypicals?

A
  1. Lower risk of EPSEs than typicals

2. But as effective as typicals

22
Q

What are the disadvantages of atypicals?

A
  1. More expensive
  2. Less experience using them
  3. Only available in oral form
23
Q

What are the S/Es of atypicals?

A
  1. Weight gain - more so than typicals
  2. Sedation
  3. Decreased seizure threshold
  4. Metabolic syndrome
24
Q

When is clozapine used?

A

Treatment-resistant schizophrenia

25
Q

What are the S/Es of clozapine?

A
  1. Agranulocytosis
  2. Sedation
  3. Constipation/dry mouth/blurred vision
  4. Weight gain
  5. Decreased seizure threshold
  6. Hypersalivation
26
Q

What is the mnemonic for good prognostic indicators in schizophrenia?

A

FINDING PLANS

F - female
I - in a relationship
N - no -ve Sx
D - aDheres to medication
I - intelligent
N - no stress
G - good pre-morbid personality
P - paranoid subtype
L - late onset
A - acute onset
N - no substance misuse
S - scan normal

Psychiatry (10 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions