Schizophrenia Flashcards
Definition of Schizophrenia
Schizophrenia is a syndrome or a disease process of the brain causing distorted and bizarre thoughts, perceptions, emotions, movements, and behaviour
- It is usually diagnosed in late adolescence and early adulthood
- Prevalence is 1% of total population, or 3 million in US; same prevalence throughout the world
Symptoms of Schizophrenia: Hard or Positive
Hard or Positive symptoms include:
- Delusions
- Hallucinations
- Grossly disorganized thinking, speech and behaviour
Symptoms of Schizophrenia: Soft or Negative
Soft of Negative symptoms include:
- Flat affect
- Avolition
- Social withdrawal or discomfort
- Apathy
- Alogia
Types of Schizophrenia: Paranoid / Disorganized
Paranoid type: persecutory or grandiose delusions and hallucinations; sometimes excessive religiosity; hostile and aggressive behaviour
Disorganized type: grossly inappropriate or flat affect, incoherence, loose associations, extremely disorganized behaviour
Types of Schizophrenia: Catatonic / Undifferentiated / Residual
Catatonic: marked psychomotor disturbance, motionless, or excessive motor activity; extreme negativism; mutism; peculiarities of voluntary movement (echolalia, echopraxia)
Undifferentiated: mixed schizophrenic symptoms along with disturbances of thought, affect, and behaviour
Residual: at least one previous psychotic episode but not currently; social withdrawal, flat affect, loose associations
Clinical Course
Most clients experience a slow and gradual onset of symptoms
Younger age of onset associated with poor outcome
In first years after diagnosis, client may have relatively symptom - free periods between psychotic episodes or fairly continuous psychosis with some shift in severity of symptoms
Most clients with schizophrenia have difficulty functioning in the community and few lead fully independent lives
Early detection and aggressive treatment of the first psychotic episode improves outcomes
Related Disorders
Schizophreniform Disorder: symptoms of schizophrenia are experienced for less than 6 months required for a diagnosis of schizophrenia
Schizoaffective Disorder: symptoms of psychosis and thought disorder along with all the features of a mood disorder
Delusional Disorder: one or more non-bizarre delusions with no impairment in psychosocial functioning
Related Disorders
Brief Psychotic Disorder: one psychotic symptom lasting 1 day to 1 month; may or may not have an identifiable stressor, such as child birth
Shared Psychotic Disorder (folie a deux): similar delusion shared by two people, one of whom has psychotic delusions
Etiology
Current etiologic theories focus on biological theories:
- Genetic factors
- Neuroanatomic theories
- Neurochemical theories
- Immunovirologic theories
Cultural Considerations
Ideas that are considered delusional in one culture may be commonly accepted in another
Auditory or visual hallucinations may be a normal part of religious experiences in some cultures
Ethnicity may be a factor in the way a person responds to psychotropic medications:
- African Americans, Caucasian Americans, and Hispanic Americans appear to require comparable therapeutic doses of antipsychotic medications
- Asian clients need lower doses of drugs such as haloperidol (Haldol) to obtain the same effects
Treatment
Primary treatment involves antipsychotic (neuroleptic) medications
Conventional antipsychotics target the positive signs
- Delusions
- Hallucinations
- Disturbed thinking
- Other psychotic symptoms
- - But have no observable effect on the negative signs
Atypical antipsychotics diminish positive symptoms, and they lessen the negative signs:
- Avolition
- Social withdrawal
- Anhedonia
Maintenance Therapy
Two antipsychotics are available in depot injection forms for maintenance therapy
- Fluphenazine (Prolixin) in decanoate and enanthate preparations
- Haloperidol (Haldol) in decanoate
The effects of the medications last from 2-4 weeks, eliminating the need for daily oral antipsychotic medication
Side Effects of Antipsychotic Medications
Neurologic Side Effects - Extrapyramidal side effects (acute dystonic reactions, akathisia, and parkinsonism) - Tardive dyskinesia - Seizures - Neuroleptic malignant syndrome Non-Neurological Side Effects - Weight gain - Sedation - Photosensitivity - Anticholinergic symptoms (dry mouth, blurred vision, constipation, urinary retention) - Orthostatic hypotension - Agranulocytosis (clozapine)
Psychosocial Treatment
Group therapies: - Supportive, medication management, use of community supports Social Skills Training - Cognitive adaptation training - Cognitive enhancement therapy (CET) Family therapy Family education
Assessment
Previous Hx with schizophrenia
Previous suicidal ideation
Current support system
Client’s perception of current situation
General appearance, motor behaviour, and speech
Mood and affect: flat or blunted affect, anhedonia
Thought processes and content: disordered
Delusions
Sensorium and intellectual processes: hallucinations, disorientation, concrete or literal thinking
Judgement and insight: impaired judgement, limited insight
Self-Concept: may be distorted, with depersonalization, loss of ego boundaries resulting in bizarre behaviours