Schizophrenia Flashcards

1
Q

What are the positive symptoms?

A

Disorders of thought/disorganised behaviour
Hallucinations
Paranoia

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2
Q

What are the negative symptoms?

A

Blunted emotions
Social withdrawal
Loss of energy
Cognitive impairment

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3
Q

What is schizophrenia?

A

Disease of the process of thought + perception

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4
Q

What are the contributing factors?

A

Nutrition of mother when in utero
Obstetric complications
Childhood trauma
Social connections
Infection
Drug misuse

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5
Q

What was the 1st anti-psychotic?

A

Chlorpromazine

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6
Q

What is suggested that the positive symptoms are due to?

A

Excess dopamine

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7
Q

Which receptor are the most important?

A

D2
D3 = negative symptoms

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8
Q

Why do you often get side effects with the medication?

A

Because they can’t specifically target D2

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9
Q

What is the 1st pathway targeted by antipsychotics?

A

Mesolimbic pathway

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10
Q

What is the location of the mesolimbic pathway?

A

Projects from ventral tegmental area (VTA)

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11
Q

What happens if there is hyperactivity in the mesolimbic pathway?

A

Positive symptoms - eg. hallucinations

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12
Q

What happens when you block the mesolimbic pathway?

A

Treats positive symptoms
BUT can blunt pleasure

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13
Q

What are the side effects of blocking the mesolimbic pathway?

A

Lack motivation
Lack of interest
Lack of joy

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14
Q

What is the 2nd pathway targeted by antipsychotics?

A

Mesocortical pathway

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15
Q

What is the location of the mesocortical pathway?

A

Pre-frontal area
Projects from VTA

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16
Q

What happens if there are hyperactivity in the mesocortical pathway?

A

Negative symptoms

17
Q

What happens if you block the mesocortical pathway?

A

May make negative symptoms + cognition worse

18
Q

What is the 3rd pathway targeted by antipsychotics?

A

Nigrostriatal pathway

19
Q

What is the location of the nigrostriatal pathway?

A

Projects from substantia nigra

20
Q

What happens if there is hyperactivity in the nigrostriatal pathway?

A

Tics
Dyskinesia

21
Q

What happens if you block the nigrostriatal pathway?

A

Dystonia (stiffness)
This is called an EPSEs

22
Q

What is an EPSE?

A

Extra pyramidal side effect

23
Q

How does tardive dyskinesia happen?

A

Chronic blocking of D2 in nigrostriatal pathway
= facial + tongue movements
= limb movements

24
Q

What is the 4th pathway targeted by antipsychotics?

A

Tuberoinfundibular pathway

25
What is the location of the tuberoinfundibular pathway?
Projects from hypothalamus
26
What happens if you block the tuberoinfundibular?
Leads to hyperprolactinemia
27
What will the ideal antipsychotic do?
Decrease dopamine in mesolimbic to treat positive + Increase dopamine in mesocortical to treat negative Whilst also Leaving dopamine tone unchanged in both nigrostriatal + tuberoinfundibular
28
What are the side effects of M1 cholinergic receptors?
Dry mouth Blurred vision Constipation Cognitive blunting
29